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#614 Surgical and histopathological outcomes of early-stage endometrial cancer treated by laparoscopic hysterectomy and sentinel node: a prospective cohort study
  1. Chrysoula Margioula-Siarkou1,
  2. Stamatios Petousis1,
  3. Emmanouela-Aliki Almperi1,
  4. Frederic Guyon1,
  5. Konstantina Mponiou2,
  6. Pavlos Papakotoulas3,
  7. George Mavromatidis4,
  8. Alexios Papanikolaou4 and
  9. Konstantinos Dinas4
  1. 12nd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki,, Thessaloniki, Greece
  2. 2Radiation Oncology Unit, Theageneio Anticancer Hospital, Thessaloniki, Greece
  3. 3Medical Oncology Unit, Theageneio Anticancer Hospital, Thessaloniki, Greece
  4. 42nd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece


Introduction/Background Sentinel node is indicated for staging of low and intermediate risk patients of apparent early-stage endometrial cancer. Main objective of the present cohort was to evaluate the surgical and histopathological outcomes of the first 30 cases in which sentinel node was performed in our ESGO-accredited Department.

Methodology Α prospective cohort study was conducted during 2020–2022 including the first 30 patients with early-stage endometrial cancer in which sentinel node technique was performed. All cases included in the present study were supervised by certified Gynaecologic Oncologist of Endoscopic Surgeon (S.P, F.G or K.D respectively). Epidemiological, surgical and histopathological outcomes of patients were recorded in a computerized database. Primary outcome of the study was to assess rates of any sentinel detection, bilateral or unilateral detection as well as to record main intraoperative and postoperative complications. Secondary outcome was to report final FIGO staging along with main histopathologic parameters.

Results Mean patients’ age was 64.5 years. Technique was performed laparoscopically in 28 cases and with laparotomy in 2 cases. At least one sentinel node was detected in all cases of the cohort. Macroscopic bilateral detection was achieved in 28 cases (93.3%), while histologically confirmed detection in 24 cases (80.0%). Non-detection concerned left side in 4 cases and right side in 2 cases. No major intraoperative or postoperative complication was observed in these cases. There was 1 case in which sentinel node was positive for nodal involvement (3.3%) and was upstaged to IIIC. Final FIGO staging was IA in 33.3% of patients (10/30), IB in 60.0% of patients (18/30), II in 6.7% of patients (2/30) and IIIC in 3.3% (1/30).

Conclusion Sentinel node is safe and effective technique with high rates of nodal status detection. Current ESGO guidelines necessitating the performance of technique in apparent early-stage endometrial cancer cases should be widely implemented by ESGO-accredited Departments.

Disclosures Authors have nothing to disclose

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