Introduction/Background The aim of this study is to observe how the operative results have changed and how the detection rates have evolved after the routine replacement of the lymphadenectomy technique by the SLNB technique.

Methodology A retrospective study was performed comparing the cohort of patients included in the prospective study of SLNB + lymphadenectomy in EC from July 2014 to December 2020 with the cohort of patients collected retrospectively from January 2021 to January 2023 of patients with EC operated on at our center using the validated SLNB technique with dual cervical and transcervical fundal injection of ICG.

In order to minimize confounding biases derived from the absence of randomization and to be able to estimate the population mean effect, inverse probability of treatment weighting (IPTW) was used, establishing a weight for each participant according to the baseline variables observed.

Results We included 442 in the analysis, Surgical staging was performed by SLNB&lymphadenectomy in 328 women if high or intermediate risk preoperative risk factors, and only by SLNB in 114.

There was a 45.5% reduction in the lymphadenectomy rates, a reduction of 0.97 days for days of hospitalization, an increase of 0.66 gr/dL of the levels of haemoglobin and an increase of detection rate for aortic, bilateral pelvic and Aortic&bilateral pelvic SLN of 12.4%, 16.3% and 14.9%.

Conclusion This study demonstrates that the incorporation of the SLNB for EC achieves a very significant reduction in the number of days of hospital stay, number of lymphadenectomies and an increase of the hemoglobin levels. We also found that once the technique was systematized all detection rates have improved, being very significant the improvement obtained at the level of bilateral pelvic detection.

Disclosures No disclosures.