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Abstract
Introduction/Background Obesity is the main risk factor for endometrioid endometrial cancer. The AHA/ACC/TOS Guideline for the Management of Overweight and Obesity states that a 5% weight loss produces clinically significant improvements in some cardiovascular risk factors such as diabetes, lipid profile, and HTA. However, there are not studies which evaluate body weight change in overweight and obese women treated for early-stage endometrial cancer and its impact on cancer outcomes
Methodology Retrospective cohort study which evaluated overweight and obese women who underwent treatment for early-stage endometrioid endometrial cancer at our center between 2007 and 2019. Body weight change at 12 months of treatment was evaluated and its impact on cancer outcomes. Also ≥ 5% weight loss was evaluated and its impact on survival.
Cumulative survival was described using Kaplan-Meier curves and log-rank tests were used to compare the curves. Logistic regression was used to perform multivariate analysis.
Results Of 526 women, 520 were included of which 77 died (17.15%). One year after treatment in the survivor group there was a significant weight loss of 1.47 6.73kg (P<0.001), meanwhile the death group presented a weight loss of 0.63 4.97 kg which was not significant (P=0.180). These body weight changes at 12 months between the survivor and the death group were not significant (OR 1.02; 95% CI:0.98–1.08, P=0.301). Multivariate analysis for death (OR 1.04; 95% CI: 0.99–1.11, P=0.16) and recurrence (OR 1.02; 95% CI: 0.97–1.09, P=0.565) were not significant for body weight change. Also, 105 (20.2%) women lost 5% or more of their total body weight by 12 months and 415 (79.8%) women maintained or gained more than 5% of their initial body weight. No significant differences were found in survival between both groups (P = 0.218).
Cumulative survival between the =5%weight loss group and the =5% weight gain group.
Conclusion Women who lose weight do not seem to have better cancer outcomes than those who do not lose weight.
Disclosures Authors declare no conflicts of interests