Introduction/Background The aim of this study was to analyze the incidence of postmenopausal bleeding (PMB) associated to the massive COVID-19 vaccination.

Methodology A retrospective observational cohort study was conducted in a single institution. All postmenopausal women who underwent an endometrial biopsy between February 2021 and January 2022 were included. Patients were classified in two groups: vaccinated or unvaccinated, according to the time between the last COVID-19 vaccine dose and the PMB or the endometrial biopsy in no PMB cases (a 30-day risk window was established).

Results 381 patients were included, 91 in the vaccinated group and 290 in the unvaccinated group. The incidence of PMB in the vaccinated group was 75.8% compared to 59.0% in the unvaccinated group (p<0.005).

Conclusion In this study, a higher incidence of PMB was associated to COVID-19 vaccine. Therefore, COVID-19 vaccines seem to be safe on this population and clinical and gynecological management should be adjusted when attending these cases.

Disclosures No disclousures