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Poster/ePoster Sessions
03. Endometrial cancer
#81 Association between recurrence, death, and after ovarian preservation in young women with early-stage endometrial cancer
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  1. Karlygash Doctor Tazhibayeva1,
  2. Doctokul Doc Tasbaltyeva2 and
  3. Assel Assel Sadykova3
  1. 1Al-farabi kazakh national university, Almatyt, Kazakhstan
  2. 2Al-farabi kazakh national university, Shymkent, Kazakhstan
  3. 3Al-farabi kazakh national university, Almaty, Kazakhstan

Abstract

Introduction/Background Endometrial cancer (EC) is the fifth most common type of cancer in women worldwide [(1)]. Global estimates of the increase in incidence, both in developed and developing countries, the indicators are almost the same [(2)]. In many cases, the diagnosis is made in postmenopausal women, but 15–25% of patients are premenopausal, and 5% are younger than 40 years [(3)].

Methodology This systemic review and meta-analysis is presented in accordance with the Multiple Admissions Regulations for Systemic Reviews and Meta-Analyses (PRISMA) and registered in the International Prospective Registry of Systemic Reviews (CRD number). We identified observational studies by searching PubMed, Medline (since 213), Embase (since 2013), Cochrane library (since 2015).

Results A US fixed effects model study found that of 3269 women identified, including 402 patients (12%) who had retained ovaries. As a result of the study of the multivariate Cox model showed that ovarian preservation did not affect either cancer-specific (hazard ratio [RR] = 0.58; 95% CI 0.14 to 2.44) or overall (RR = 0.68 ; 95% CI) 0.34–1.35) survival.

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Conclusion The current study showed that there was no significant difference in relapse-free survival between patients with preserved ovaries of stage IA and partially stage II and patients with bilateral salpine oovariectomy. This study suggests that the preservation of ovaries in the early stages of endometrial cancer in premenopausal women after a full explanation of the possible risk of the disease and a thorough preoperative evaluation in rolna may be a safe choice. Interpretation of our results should take into account some shortcomings of this study. Firstly, the sample size was insufficient in some studies, and there was no significant difference in the recurrence rate between the ovarian preservation and BSO groups. Secondly, we did not separate laparotomy and laparoscopic treatments separately, we focused on the outcome of treatment.

Disclosures Searched Medline, Embase, Cochrane Library

https://doi.org/10.1136/ijgc-2023-ESGO.271

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