Introduction/Background The possibility of adequate staging while avoiding systematic lymphadenectomy leads to a significant reduction in the rate of peri- and postoperative morbidity in patients with endometrial cancer (EC). Indocyanine green (ICG) with near-infrared (NIR) fluorescence imaging is a new tracer modality used for lymphatic mapping. We report our experience with ICG for SLN mapping in patients with early stage EC (stages IA-IB).
Methodology Intracervical injection of ICG at 3 and 9 o’clock at a concentration of 0.5 mg/ml was performed in all cases. Sensitivity and specificity values were calculated.
Results A total of 18 patients were included in the study. The median age was 61 (29–76) and median body mass index was 29 (20–46). The median SLN count was 3.2 (1–6). The overall and bilateral detection rate was 95% and 86%. Sensitivity, specificity and negative predictive value were 92.3%, 100% and 96.8% respectively per side. There were no allergic reactions to the ICG.
Conclusion NIR fluorescence imaging with ICG is an excellent and safe tracer modality for SLN mapping with a very high overall (95%) and bilateral (86%) detection rate. Therefore, SLN mapping is efficient in identifying metastatic nodal disease without compromising oncological safety.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.