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Poster/ePoster Sessions
03. Endometrial cancer
#29 Cytology and LVSI evaluation as a poor prognostic factor in uterine cancer: 11 years single center experience
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  1. Cem Yagmur Ozdemir1,
  2. Nayif Cicekli1,
  3. Dagistan Tolga Arioz1,
  4. Mariam Chkhikvadze1,
  5. Filiz Bilir2,
  6. Nefize Vatansever3 and
  7. Sezgin Yilmaz1
  1. 1Afyonkarahisar Health Sciences University Medical Faculty Hospital, Afyonkarahisar, Turkey
  2. 2Sakarya University Faculty of Medicine, Sakarya, Turkey
  3. 3Izmir Cigli Regional Training and Research Hospital, Izmir, Turkey

Abstract

Objective To emphasize the effect of lymphovascular space invasion (LVSI) and cytology positivity on prognosis in addition to molecular classification.

Methodology Methods : The records of 223 patients with endometrial cancer between January 2011 and January 2022 were retrospectively reviewed. The Kaplan-Meier method was used to evaluate overall survival (OS) and progression -free survival (PFS). Survival rates; were compared in terms of stage, tumor histology, grade, body mass index(BMI), cytology and lymphovascular space invasion (LVSI).

Results Of the 223 patients with endometrial cancer overall 5-year survival was 82.4%, the recurrence-free survival was 88.3%. The 5-year PFS of LVSI negative patients was 93% and LVSI positive patients was 77.3% of (p<0.001). The 5-year PFS of cytology-negative patients was 90.4%, and 77.1% of cytology-positive patients (p<0.05).

Abstract #29 Figure 1
Abstract #29 Figure 1

Conclusion As a result, LVSI positivity, non-endometrioid histological type, high stage and cytology positivity are poor prognostic factors. As we found in our study, LVSI positivity, non-endometrioid histological type, high stage and cytology positivity also reduce the overall survival rate. In this study, we wanted to emphasize that in addition to molecular classification, cytology and LVSI positivity are still very important factors in prognosis.

Discussion We found in our study, LVSI positivity, non-endometrioid histological type, high stage and cytology positivity also reduce the overall survival rate. In this study, we wanted to emphasize that in addition to molecular classification, cytology and LVSI positivity are still very important factors in prognosis.

https://doi.org/10.1136/ijgc-2023-ESGO.264

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