Introduction/Background Given the relative frequency of adenocarcinomas, the literature has sought to estimate the occurrence of undetected cases of endometrial cancer in perimenopausal women undergoing hysterectomy for benign indications.

This study aims to shed light on the prevalence of undetected endometrial cancer and emphasize the importance of thorough evaluation of the endometrium in perimenopausal women undergoing hysterectomy for benign conditions.

Methodology A prospective study of eight months collecting data from perimenopausal patients who underwent hysterectomy for benign indications.

Results We collected data from 24 perimenopausal patients. The mean age was 49 years (47 to 52). The mean parity was 3 (0 to 7). Twelve patients had hypertension, two of whom also had diabetes. No family or personal history of gynecological or colorectal cancer was reported.

Surgical indications included four cases of urogenital prolapse, 12 cases of chronic pelvic pain associated with uterine fibroids, and eight cases of treatment-resistant metrorrhagia.

Six patients had suspicious endometrium on ultrasound and underwent hysteroscopy with endometrial biopsy: four cases of simple hyperplasia without atypia, one case of endometrial polyp, and one case of complex hyperplasia without atypia.

Histopathological examination of the hysterectomy specimens revealed one case of grade I adenocarcinoma in a 52-year-old patient with hypertension, a 10mm endometrium, and a polyfibromatous uterus. The initial biopsy showed complex hyperplasia without atypia.

Conclusion In conclusion, hysterectomy continues to be a prevalent gynecological procedure performed for benign indications in perimenopausal women. However, considering the potential occurrence of undetected endometrial cancer in this population, it is crucial to emphasize the importance of preoperative evaluation. Comprehensive assessment, including clinical examination, ultrasound imaging, and histopathological examination of the endometrium, is recommended to ensure accurate diagnosis and appropriate management.

Disclosures The findings of this study underscore the importance of preoperative evaluation in perimenopausal women undergoing hysterectomy for benign indications. While every effort has been made to provide accurate and reliable information, it is essential to note that this study was conducted within a specific timeframe and at a particular medical center. Therefore, the results and conclusions may not be generalized to other populations or settings without further validation.