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#830 HPV in clinical hospital center sestre milosrdnice – four-year period
  1. Ivana Stojanovic1,
  2. Ivan Samija1,
  3. Drazan Butorac1 and
  4. Adriana Semper Majdandzic2
  1. Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia
  2. General Hospital Bjelovar, Bjelovar, Croatia


Introduction/Background Human papillomavirus (HPV) is the most common sexually transmitted infection. It can cause serious health problems such as warts, carcinoma of vulva, vagina, cervix, penis, anus and oropharynx or recurrent respiratory papillomatosis and some cutaneous diseases. There are over than 200 types of HPVs. HPV 16 and 18 cause about 70% of cervical cancers. HPV 6 and 11 cause about 90% warts.

Methodology Between January 2017 and December 2020, 853 HPV typings were performed at Clinical Hospital Center Sestre milosrdnice. The samples were taken in gynecology (806), otorhinolaryngology (39), dermatology (7) and pediatric (1) clinics. The most common diagnoses were low and high grade squamous intraepithelial lesion (LSIL and HSIL), cervical carcinoma in situ (CIS), cervical carcinoma, warts, lingual carcinoma, oropharyngeal carcinoma, hard palate cancer, recurrent respiratory papillomatosis and oropharyngeal, laryngeal or vocal papilloma.

Results Among otorhinolaryngological patients, 74,4% were HPV negative, 7,7% were HPV 16 positive, followed by HPV 56 (5,1%), 18 (2,5%), 31 (2,5%), 52 (2,5%), 39 (2,5%), 59 (2,5%). Among dermatological patients, 57,1% were HPV negative, 2,86% HPV 51 positive and 1,4% HPV 39 positive. There was one pediatrics patient and he was HPV negative. Among gynecological patients, 54,3% were HPV negative and 12,2% were HPV 16 positive. There was 8,4% inadequate samples. Rest of the gynecological patients had HPV 31 (5,3%), HPV 35 (4,3%), HPV 18 (2,3%), HPV 33 (2,2%), HPV 52 (1,8%), HPV 56 (1,7%), HPV 39 (1,6%), HPV 51 (1,4%), HPV 45 (1,1%), HPV 59 (1,1%), HPV 66 ( 0,6%), HPV (0,1%).

Conclusion Only high-risk HPV typing was done. It is expected that most dermatological samples will be HPV negative. The most frequent oral HPV is HPV-16. The main indication for HPV testing in gynecology in our hospital is the six-month follow-up after LLETZ or cold knife conization.

Disclosures All authors declare that they have no conflicts of interest.

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