Introduction/Background Granular cell tumors involving the breast are very rare, accounting for 5% to 8% of all granular cell tumors. They can mimic a carcinoma witch make diagnosis difficult. The histological evaluation is essential to differentiate between both.

Methodology Five cases of granular cell tumor (GCT) of the breast are reviewed. The demographics and clinical features are reviewed and the radiologic and pathologic features as well as the immunohistochemistry are discussed.

Results Three of the five cases occurred in woman and two occurred in a male patient .All of the granular cell tumor presented as solitary nodule with right breast in three patients .The mean age at the moment of diagnosis was 35 years (19 years -53 years). All five tumors exhibited imaging features highly suggestive of malignancy (BI-RADS 5 lesions).All tumors were diagnosed by core biopsy, and the tumors were excited in all all cases. The mean pathological size was 1.98 cm. None of our cases presented with enlarged lymph nodes. All the cases showed strong positive staining for S-100 protein; CD 68, vimentine and negative staining for CK7. None of the tumors have recurred.

Disclosures Granular cell tumor of the breast is a rare tumor, often benign. The presence of criteria of malignancy must retain the vigilance of the clinician and the pathologist and encourage close clinical and radiological surveillance of the patient.