Introduction/Background Most Cervical Cancer patients in LMICs usually present in advanced stages of the disease which is associated with health and psychological difficulties affecting their quality of life.

Methodology A prospective longitudinal study with a two-point assessment of the QOL of participants at the time of diagnosis of cervical cancer and after treatment. Participants were recruited from one randomly selected tertiary-level health facility in each of the six geopolitical zones in Nigeria. The study lasted for twelve months. Newly diagnosed cervical cancer patients were recruited consecutively after informed consent and ethical clearance. QOL was assessed using Quality of Life Questionnaire domains (EORTC QLQ30). The primary outcome was QOL at diagnosis of Cervical cancer and after treatment. The Secondary outcome was the relationship between sociodemographic factors, clinical variables, and QOL. The quality of life were graded into 5(15 & less- very good,16–30 – Good, 31–60 – poor,61 -75 – very poor and 76 & higher – worst) Statistical analysis was done using SPSS 25

Results A total of 157 newly diagnosed Cervical Cancer patients were recruited. While 23(14.6%) participants were lost to follow-up, 134 (85.4%) were utilized for the comparison of QoL between the two periods. The commonest age at presentation was 46-55 years (33.1%). Most patients presented at an advanced stage {stage 3 (51%), stage 2 (29.3%), stage 4 (8.3%]. The majority presented with poor QoL {1.9% (good), 60.5% (poor), 14.6% (very poor), and 15.7% (worst QoL)}. A significant improvement in QoL (p=0.040) was recorded after treatment (5.2% - good, 79.9% - poor, 11.2% - very poor, and only 3.7% recorded worst QoL).

Conclusion Quality of life of newly diagnosed cervical cancer patients in Nigeria is poor though treatments improve quality of life in some of the patients. There is a need for more studies, especially in LMICs on the quality of life for gynecological cancer

Disclosures The study was funded by Gynecologic Cancer InterGroup (GCIG), Cervical Cancer Research Network (CCRN)