Introduction/Background The presence of MMR-deficiency along with LVSI positivity may indicate a more aggressive form of endometrial cancer and is an important factor to consider in patient monitoring and treatment planning.Studies evaluating the relationship between MMR-deficiency and LVSI positivity in endometrial cancer have been conducted.These studies have generally observed a higher prevalence of LVSI positivity in endometrial cancer cases with MMR-deficiency.The aim of our study is to investigate the presence of this relationship using a large dataset from a tertiary center.

Methodology The study was designed as a retrospective case-control study.The research involved the examination of data from all patients diagnosed with endometrial cancer who presented to our clinic between June 2020-May 2023.The aim of this study was to investigate the relationship between LVSI negative,focal,and substantial positivity and MMR-gene defect.The statistical method used was the Pearson Chi-Square test.

Results A total of 226 patients with endometrial cancer were included.The mean age of the patients,whose age range was between 23 and 88 years,was 60.64±10.59.The number of patients with positive lymphovascular space invasion was 81,and the number of patients with negative invasion was 145.While the number of patients with MMR-deficits was 58,the number of patients with proficiency was 168.A significant correlation was found between MMRd patients and LVSI positivity(p< 0.05)(table 1).

Conclusion The MMR-defect suggests that tumors may have a tendency to be more invasive and spread to lymphovascular spaces.McMeekin et al.found that women with tumors with MMR-defects were more likely to have higher-grade cancers and more frequent lymphovascular space invasion.In our study, a significant association was observed between patients with MMR-deficiency and the presence of lymphovascular space invasion(LVSI),which is supported by the existing literature.In some cases,positive survival trends are detected in patients with MMR-defects,while in other cases,this relationship is not evident.Therefore,further research is required to fully understand the relationship between MMR-defect and lymphovascularspace invasion.

Disclosures There are no conflicts of interest to disclose