Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study

Robert D Morgan; Andrew R Clamp; Bethany M Barnes; Kirsten Timms; Helene Schlecht; Laura Yarram-Smith; Yvonne Wallis; Mikel Valganon-Petrizan; Suzanne MacMahon; Rhian White; Sian Morgan; Sarah McKenna; Emma Hudson; Laura Tookman; Angela George; Ranjit Manchanda; Sudha S Sundar; Shibani Nicum; James D Brenton; Rebecca S Kristeleit; Susana Banerjee; Iain A McNeish; Jonathan A Ledermann; Stephen S Taylor; D Gareth R Evans; Gordon C Jayson

doi:10.1136/ijgc-2022-004211

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Original research

Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study

Authors

Robert D Morgan The Christie NHS Foundation Trust, Manchester, UK Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Andrew R Clamp The Christie NHS Foundation Trust, Manchester, UK Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Bethany M Barnes Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Kirsten Timms Myriad Genetics, Inc, Salt Lake City, Utah, USA PubMed articles Google scholar articles
Helene Schlecht North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Laura Yarram-Smith South West Genomic Laboratory Hub, North Bristol NHS Trust, Bristol, UK PubMed articles Google scholar articles
Yvonne Wallis Central and South Genomic Laboratory Hub, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK PubMed articles Google scholar articles
Mikel Valganon-Petrizan North Thames Genomic Laboratory Hub, The Royal Marsden Hospital NHS Foundation Trust, Surrey, UK PubMed articles Google scholar articles
Suzanne MacMahon North Thames Genomic Laboratory Hub, The Royal Marsden Hospital NHS Foundation Trust, Surrey, UK PubMed articles Google scholar articles
Rhian White All Wales Genomics Laboratory, Institute of Medical Genetics, University Hospital Wales, Cardiff, UK PubMed articles Google scholar articles
Sian Morgan All Wales Genomics Laboratory, Institute of Medical Genetics, University Hospital Wales, Cardiff, UK PubMed articles Google scholar articles
Sarah McKenna Belfast Health and Social Care Trust, Belfast, UK PubMed articles Google scholar articles
Emma Hudson Velindre University NHS Trust, Cardiff, UK PubMed articles Google scholar articles
Laura Tookman Imperial College Healthcare NHS Trust, London, UK PubMed articles Google scholar articles
Angela George The Royal Marsden NHS Foundation Trust, London, UK The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Ranjit Manchanda Barts Health NHS Trust, London, UK Department of Health Services Research, The Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK Wolfson Institute of Population Health, Queen Mary's University of London, London, UK PubMed articles Google scholar articles
Sudha S Sundar Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
Shibani Nicum University College London Hospitals NHS Foundation Trust, London, UK UCL Cancer Institute, London, UK PubMed articles Google scholar articles
James D Brenton Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK CRUK Cambridge Institute, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Rebecca S Kristeleit Guy’s and St Thomas’ NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Susana Banerjee The Royal Marsden NHS Foundation Trust, London, UK The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Iain A McNeish Imperial College Healthcare NHS Trust, London, UK Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK PubMed articles Google scholar articles
Jonathan A Ledermann University College London Hospitals NHS Foundation Trust, London, UK UCL Cancer Institute, London, UK PubMed articles Google scholar articles
Stephen S Taylor Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK PubMed articles Google scholar articles
D Gareth R Evans Manchester University NHS Foundation Trust, Manchester, UK Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Gordon C Jayson The Christie NHS Foundation Trust, Manchester, UK Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK PubMed articles Google scholar articles

Correspondence to Dr Robert D Morgan, The Christie NHS Foundation Trust, Manchester, UK; robert.morgan7{at}nhs.net

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Citation

Morgan RD, Clamp AR, Barnes BM, et al

Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study

International Journal of Gynecologic Cancer 2023;33:1253-1259.

Publication history

Received December 12, 2022
Accepted April 7, 2023
First published April 18, 2023.

Online issue publication

October 18, 2023

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