Background Advances in the treatment of gynecological cancers have led to increased survival in patients with gynecological cancers. Nevertheless, patients may still experience prevalent long term consequences, including lower limb lymphedema, depression, anxiety, sexual dysfunction, malnutrition, and sarcopenia, that negatively impact their quality of life.

Primary Objective To assess the impact on self-perceived quality of life of systematic screening and early treatment of lower limb lymphedema, anxiety and depression, sexual dysfunction, and sarcopenia and malnutrition compared with standard practice.

Study Hypothesis Systematic screening with validated questionnaires leading to early diagnosis and treatment of side effects will have a positive impact on quality of life.

Trial Design This prospective clinical trial will randomize candidates for surgery to either standard of care or systematic screening every 2 months for 2 years. Quality of life data will be collected every 4 months. After randomization, patients in the control group will follow standard usual care. Their screening scales will not be considered. In the experimental group, positive screenings will generate an alert to the physician, and patients will be referred to the corresponding specific area (rehabilitation unit, psycho-oncology unit, sexual health unit, or nutrition unit).

Major Inclusion and xclusion Criteria Patients aged ≥18 years with ovarian, cervical, or endometrial cancer who are candidates for surgery will be included.

Primary Endpoint Self-reported quality of life questionnaire score.

Sample Size 168 patients will be randomized to detect a difference of 6 points in the questionnaires.

Estimated Dates for Completing Accrual and Presenting Results Study completion is estimated for January 2026 and the results will be presented in May 2026.

Trial Registration number NCT05918770.