Introduction/Background Cervical cancer is the fourth most commonest malignancy in women all over the world. It is widely dominated by squamous cell carcinoma. Adenocarcinoma accounts for only 10% of these tumors, dominated by the endocervical subtype. Other histologic subtypes remain very rare.

Methodology We conducted a retrospective study at Salah Azaiez Institute between 2002 and 2022. We collected 15 cases of non-squamous cell carcinomas of the cervix. We analyzed the clinicopathological features of these rare malignancies.

Results Among the 15 cases, 11 cases were diagnosed with an adenosquamous carcinoma, 2 with a mesonephric carcinoma, and 2 with an adenoid basal carcinoma. The median age of our patients was 56 years(31–79 years). The main symptom was metrorrhagia and only 1 patient described abdominal pain. According to FIGO 2018 classification, 2 patients were staged IIB and 1 patient was staged IB3. All patients underwent Radio-chemotherapy and then surgery. For the adenosquamous carcinoma, the diagnosis was conducted in a biopsy specimen in 13 cases. An immunohistochemistry study was needed to confirm the diagnosis in 3 cases with the positivity of ACE. The mesonephric carcinoma was diagnosed on a hysterectomy specimen and no immunohistochemistry was needed to confirm the diagnosis. the adenoid basal carcinoma was c kit positif in immunohistochemistry study.

Conclusion Cervical cancer remains in increased progress, especially in developing countries. More multicentric studies are necessary to establish the demographic, the histopathological characteristics, and the adequate treatment for these rare tumors.