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2022-RA-1664-ESGO Consensus radiotherapy guidelines vulvar cancer: Spanish GINECOR/SEOR group modified Delphi study
  1. Sofia Cordoba Largo1,
  2. Isabel Rodriguez2,
  3. Javier Anchuelo Latorre3,
  4. Dina Najjari Jamal4,
  5. Silvia Rodriguez Villalba5,
  6. Cristina de la Fuente6,
  7. Francisco Celada Álvarez7,
  8. Sonia García Cabezas8,
  9. María Sanchez Belda9,
  10. Elena Villafranca Iturre10,
  11. Belen Belinchon Olmeda11,
  12. Luz Couselo Paniagua12,
  13. Irene Martínez10,
  14. Paola Navarrete3 and
  15. Dolores Farga7
  1. 1Radiation Oncology, Hospital Puerta de Hierro, Majadahonda, Madrid, Spain
  2. 2Radiation Oncology, Hospital Universitario La paz, Torrelodones, Spain
  3. 3Hospital Universitario Marqués de Valdecilla, Radiation Oncology, Santander, Spain
  4. 4Instituto Catalán de Oncología, Radiation Oncology, Barcelona, Spain
  5. 5Hospital Clínica Benidorm, Radiation Oncology, Alicante, Spain
  6. 6Hospital Uiversitario Puerta de Hierro de majadahonda, Madrid, Spain
  7. 7Hospital Universitario y Politécnico La Fe, Radiation Oncology, Valencia, Spain
  8. 8Hospital Universitario Reina Sofía, Radiation Oncology, Córdoba, Spain
  9. 9Hospital Clínico Universitario de Valladolid, Radiation Oncology, Valladolid, Spain
  10. 10Complejo Hospitalario de Navarra, Radiation Oncology, Pamplona, Spain
  11. 11Hospital Universitario La paz, Madrid, Spain
  12. 12Hospital Clínico Universitario de Santiago., Radiation Oncology, Santiago de Compostela, Spain


Introduction/Background Due to the low incidence of vulvar cancer, there are very few randomized studies for decision making in these patients. Current recommendations are mostly based on retrospective studies and institutional experience. The present consensus was developed by a team of spanish radiation oncologists on behalf of the subgroup GINECOR of the Spanish Society of Radiation Oncology, (SEOR) to provide a current review of the radiation treatment of vulvar cancer (VC).

Methodology A national panel of experts were recruited to reach consensus on the radiation treatment of VC. Prior to the discussion of the statements, we performed an extensive analysis of current medical literature from peer-reviewed journal to define evidence-based treatment options. A 2-round web-based modified Delphi study was conducted to reach a consensus on the appropriateness of the different therapeutic options in each clinical setting. The appropriateness of various therapies was classified as strongly agree, agree, neither agree nor disagree, disagree, strongly disagree. In those instances where evidence is lacking or not definitive, expert opinion was used to formulate recommendations.

Results Recommendations are made for using radiotherapy focused on the indications of radiotherapy. Three clinical scenarios were defined: adjuvant treatment, locally advanced vulvar cancer and recurrent disease. A high level of agreement over 80% was reached. Adjuvant radiotherapy is recommended for resected vulvar carcinoma with adverse risk factors, mainly positive margins and lymph nodes. For patients with unresectable vulvar carcinoma EBRT with or without chemotherapy should be considered. The approach to a recurrence of vulvar carcinoma must be individualized for each patient in different clinical scenarios

Abstract 2022-RA-1664-ESGO Table 1

Conclusion In those aspects of vulvar cancer where evidence is not definitive, expert panel consensous may help in clinical decision-making

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