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Vaginal and vulvar cancer
2022-RA-1299-ESGO How to predict preoperative risk of lymph node metastasis in vulvar cancer patients the Morphonode Predictive Model
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  1. Simona Maria Fragomeni1,
  2. Francesca Moro1,
  3. Fernando Palluzzi2,
  4. Alex Federico1,
  5. Sonia Bove3,
  6. Floriana Mascilini1,
  7. Federica Pozzati1,
  8. Giovanni Scambia1,4,
  9. Antonia Carla Testa1,4 and
  10. Giorgia Garganese4,3
  1. 1Unità di Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
  2. 2Bioinformatics Facility, Gemelli Science and Technology Park (GSTeP), Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
  3. 3Gynecology and Breast Care Center, Mater Olbia Hospital, Olbia, Italy
  4. 4Dipartimento Universitario Scienze della Vita e Sanità Pubblica Sezione di Ginecologia ed Ostetricia, Università Cattolica del Sacro Cuore, Rome, Italy

Abstract

Introduction/Background Preoperative evaluation of inguinal lymph nodes in vulvar cancer patients is still a challenge. Our aim was to build a robust, multi-modular ultrasound model based on artificial intelligence.

Methodology From March 2017 to April 2020, 127 women were included at our center and 237 inguinal regions were studied before surgery by ultrasound experienced examiners. Ultrasound features defined in previous studies were prospectively collected. Histopathology was considered the reference standard. Fourteen informative features were used to train and test the machine, in order to obtain a diagnostic model. The following data classifiers were integrated into the predictive model: 1) random forest classifiers (RCF); 2) decisional tree (DT); 3) regression binomial model (RBM); 4) similarity profiling (SP). A predictive tool was implemented in the open-source R package, available on line as ‘Morphonode Predictive Model’ at https://github.com/Morphonodepredictivemodel.

Results The tool provides four output modules: 1) the binary malignancy prediction (Morphonode-RFC), distinguishing between malignant and benign lymph nodes with an accuracy of 93.3% and a negative predictive value of 97.1% (95%CI 83.8–100.0); 2) the risk signature (Morphonode-DT), identifying 4 specific signatures correlated with the risk of metastases: metastatic signature (MET), high metastatic risk (HMR), moderate metastatic risk (MMR) and low metastatic risk (LMR); the point risk of metastasis for each signature is 100%, 81%, 16% and 4% respectively; MET signature correlates with higher risk for multiple metastatic nodes (frequency of 45.7%); 3) the point malignancy risk, providing a point risk estimate in each specific lymph node described (Morphonode-RBM); 4) a selection of the top- 5 similar profiles in the study series, supporting the clinician to integrate output analysis (Morphonode-SP).

Conclusion Our findings indicate that Morphonode Predictive Model is a simple and observer-independent tool. It could be easily integrated in the clinical routine for preoperative stratification of vulvar cancer patients.

https://doi.org/10.1136/ijgc-2022-ESGO.961

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