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Quality of life after treatment
2022-RA-222-ESGO Quality of life after extended pelvic exenterations
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  1. Štefan Lednický1,
  2. Eva Hoschlová2,
  3. Jiří Sláma1,
  4. Markéta Wiesnerová3,
  5. Petr Mitáš4,
  6. Zdeněk Matějovský5,
  7. Michaela Schneiderová6,
  8. Pavel Dundr7,
  9. Kristýna Němejcová7,
  10. Andrea Burgetová8,
  11. Libor Zámečník9,
  12. Michal Vočka10,
  13. Roman Kocián1,
  14. Filip Fruehauf1,
  15. Lukáš Dostálek1,
  16. Daniela Fischerová1,
  17. Martina Borčinová1 and
  18. David Cibula1
  1. 1Gynaecologic oncology centre, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
  2. 2Department of Psychology, Faculty of Arts, Charles University in Prague, Prague, Czech Republic
  3. 3Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic
  4. 4Second surgical clinic – cardiovascular surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
  5. 5Department of Orthopaedics, First Faculty of Medicine, Charles University and Hospital Na Bulovce, Prague, Czech Republic
  6. 6First surgical clinic – thoracic, abdominal and injury surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
  7. 7Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
  8. 8Department of radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
  9. 9Clinic of urology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
  10. 10Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Abstract

Introduction/Background Pelvic exenteration (PE) remains a standard of care procedure in patients with recurrent pelvic malignancies, especially after primary radiotherapy. New procedures allow to reach free surgical margins in selected patients with tumours attaching/invading pelvic side-wall structures. However, little has been published about quality of life (QoL) after these more extensive surgeries, carrying new types of morbidity especially after resection of large nerves (femoral and sciatic), vessels, or pelvic bones. The aim of the presented study was to compare the quality of life of patients after PE and extended pelvic exenteration (EPE).

Methodology Data from 74 patients who underwent PE (42) or EPE (32) between 2004 to 2019 at a single tertiary gynae-oncology centre in Prague were analysed. EPEs were defined as procedures including resection of internal, external, or common iliac vessels, pelvic side-wall muscles, large pelvic nerves, or pelvic bones (figure 1). Quality of life assessment was performed in surviving patients using EORTC QLQ-C30, EORTC CX-24, and QOLPEX questionnaire developed and validated specifically for patients after extensive pelvic procedures. Two sided Mann-Whitney U test with Bonferroni correction was used for QoL comparisons.

Results With median follow-up of 23.5 months, median overall survival in the whole cohort was 45 months, and median disease-specific survival 49 months. No significant differences in survival were observed between the groups (P >0.999). Thirty-one patients participated in the QoL surveys (20 PE, 11 EPE). Most patients reported good level of physical, emotional, and cognitive functions. No evidence of QoL difference between groups was found, nor did we observe differences in the willingness to undergo treatment again. Both groups reported good satisfaction with their respective therapy

Abstract 2022-RA-222-ESGO Figure 1
Abstract 2022-RA-222-ESGO Figure 1

Conclusion EPE are associated with similar post-treatment QoL and survival as traditional PE. These procedures offer potentially curative treatment option for patients with recurrent pelvic tumour attaching/invading pelvic wall structures.

https://doi.org/10.1136/ijgc-2022-ESGO.836

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