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2022-RA-1190-ESGO A conservative treatment of CIN II using a Coriolus versicolor-based vaginal gel: an observational study
  1. Nadia Nassar Melic,
  2. Miguel Díaz Vega,
  3. Silvia Herrero Barrios,
  4. Gemma Pardina Claver and
  5. Marta Padina Fabeiro
  1. Obstetrics and Gynecology Service in Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain


Introduction/Background Human papilloma virus infection is the most common venereal disease and is behind 95% of cervical cancer cases and its precursor lesions. According to the American Society of Colposcopy and Cervical Pathology (ASCCP), 50% of CIN II cases managed conservatively spontaneously regress. The aim of this study was to evaluate the effect of a Coriolus versicolor-based vaginal gel in the conservative management of CIN II lesions.

Methodology A one-cohort, prospective, single-centre, observational study including women ≥ 18 years old, with a CIN II diagnosis who were treated with 1 cannula/day for 1 month + 1 cannula/alternate days for 5 months of Coriolus versicolor-based vaginal gel, was performed. Inclusion criteria was based on the Spanish Society of Colposcopy and Cervical Pathology (AEPCC) guidelines for CIN II conservative treatment: adequate colposcopy image with visible transition zone, completely visible lesion affecting less than 2 quadrants, non-affected endocervix and accepting cytology/colposcopy after 6 months. Baseline and 6-month biopsies were performed.

Results A total of 44 women with an average age of 35.5 years were included. After 6 months, 68.2% of them shown a regression by biopsy. From the rest of the patients 11.4% persisted on CIN II and 18.2% progressed to CIN III. Three patients were considered null and not included in the data analysis because they did not have a biopsy taken after 6 months.

Conclusion The application of Coriolus versicolor-based vaginal gel seems to increase regression of the lesions compared to spontaneous resolution and could represent a clinical advantage compared to the ‘wait and see’ approach in patients meeting the conservative treatment criteria for CIN II lesions.

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