Introduction/Background Epithelial Ovarian Cancer (EOC) is still the most lethal gynecological malignancy, with approximately 21,410 new cases and 13,770 deaths in the USA in 2021. Many theories have been proposed in terms of clarifying the etiology and the carcinogenesis -mechanism of EOC. Based on the latest trends, ovarian, fallopian tube, and peritoneal cancer are incorporated into the same group as it is suggested that high-grade extrauterine tumors of serous histology originate from the fallopian tube.
Methodology We ex vivo collect salpingeal epithelial cellsfrom the fibria directly from fresh fallopian tube specimensfrom women undergoing salpingectomy for any indication. The cytomorphological characteristics of the salpingeal cells are subsequently being evaluated and categorised into malignant and non -malignant. Finally, the ipsilateral adnexaeare examined with the SEE-FIM (Sectioning and Extensively Examining the FIMbriated End) protocol and the pathology reports are corelated with the cytological findings. Our research protocol is ongoing and is designed to include a total of 300 patients in order to confirm the sensitivity and specificity of salpingeal cytology as a method in the early diagnosis of extrauterine gynecological malignancies.
Results So far, we have obtained 343 salpingeal brushingsfrom a total of 214 patients. The sensitivity of cytology regarding distinguishing malignant from non-malignant tumors,was 69.64% (95% CI: 55.90% – 81.22%), while its specificity 75.96% (95% CI: 70.59% – 80.79%). Cytology’s positive predictive value (PPV) was 16.33% (95% CI: 12.57% – 20.67%), while the negative predictive value (NPP) reached 92.77% (95% CI: 89.56% – 95.04%). In general, the diagnostic accuracy of the cytological evaluation reaches 74.93% (95% CI: 66.99% – 79.43%).
Conclusion Salpingeal cytomorphologic evaluation appears to be a promising method to detect adnexal cancer. Our study, aims in the long term to validate the oncological efficacy of tubal cytology as an early diagnosis tool against gynecological extrauterine malignancies.
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