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Pathology
2022-RA-442-ESGO Fallopian tube cytological findings in women undergoing salpingectomy and correlation with the adnexal pathology
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  1. Viktoria Psomiadou1,
  2. Sofia Lekka1,
  3. Theodoros Panoskaltsis2,
  4. Eleni Tsouma3,
  5. Natasa Novkovic3,
  6. Helen Trihia4,
  7. Olympia Tzaida4,
  8. Dimitrios Korfias1,
  9. Panagiotis Giannakas1,
  10. Christos Iavazzo1,
  11. Christos Papadimitriou5,
  12. Nikolaos Vlahos2 and
  13. George Vorgias1
  1. 1Gynaecological Oncology, Metaxa Memorial Cancer Hospital, Piraeus, Athens, Greece
  2. 2Second Department of Obstetrics and Gynecology, Medical School, University of Athens ‘’Aretaieio’’ Hospital, Athens, Greece
  3. 3Cytology Laboratory, Metaxa Memorial Cancer Hospital, Piraeus, Athens, Greece
  4. 4Pathology, Metaxa Memorial Cancer Hospital, Piraeus, Athens, Greece
  5. 5Oncology Unit, 2nd Department of Surgery Aretaieion Hospital, The National and Kapodistrian University of Athens, Athens, Greece

Abstract

Introduction/Background Epithelial Ovarian Cancer (EOC) is still the most lethal gynecological malignancy, with approximately 21,410 new cases and 13,770 deaths in the USA in 2021. Many theories have been proposed in terms of clarifying the etiology and the carcinogenesis -mechanism of EOC. Based on the latest trends, ovarian, fallopian tube, and peritoneal cancer are incorporated into the same group as it is suggested that high-grade extrauterine tumors of serous histology originate from the fallopian tube.

Methodology We ex vivo collect salpingeal epithelial cellsfrom the fibria directly from fresh fallopian tube specimensfrom women undergoing salpingectomy for any indication. The cytomorphological characteristics of the salpingeal cells are subsequently being evaluated and categorised into malignant and non -malignant. Finally, the ipsilateral adnexaeare examined with the SEE-FIM (Sectioning and Extensively Examining the FIMbriated End) protocol and the pathology reports are corelated with the cytological findings. Our research protocol is ongoing and is designed to include a total of 300 patients in order to confirm the sensitivity and specificity of salpingeal cytology as a method in the early diagnosis of extrauterine gynecological malignancies.

Results So far, we have obtained 343 salpingeal brushingsfrom a total of 214 patients. The sensitivity of cytology regarding distinguishing malignant from non-malignant tumors,was 69.64% (95% CI: 55.90% – 81.22%), while its specificity 75.96% (95% CI: 70.59% – 80.79%). Cytology’s positive predictive value (PPV) was 16.33% (95% CI: 12.57% – 20.67%), while the negative predictive value (NPP) reached 92.77% (95% CI: 89.56% – 95.04%). In general, the diagnostic accuracy of the cytological evaluation reaches 74.93% (95% CI: 66.99% – 79.43%).

View this table:
Abstract 2022-RA-442-ESGO Table 1

Cross-tabulation cytology- adnexal pathology

Conclusion Salpingeal cytomorphologic evaluation appears to be a promising method to detect adnexal cancer. Our study, aims in the long term to validate the oncological efficacy of tubal cytology as an early diagnosis tool against gynecological extrauterine malignancies.

https://doi.org/10.1136/ijgc-2022-ESGO.788

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