Introduction/Background The use of HIPEC is still controversial since there is no consensus about its benefits and implementation in the current literature.We present a descriptive analysis of the results in a single reference center gynecologic oncology unit

Methodology We did a retrospective observational study from 2015 to 2019.We included every women who underwent CRS+HIPEC procedure during the study period. Demographic data,pre and post operatory data,OS and PFS and current status were registered

Results 35 patients were included.Preanestesic risk was low in 87% of cases(ASA I-II).62,9%(n=22) of patients were treated initially with CRS vs 37,1%(n=13) who received neoadyuvant chemotherapy.In our sample,the most frequent timing of HIPEC was after relapse(45,7%).Laparotomic approach was the most frequent representing 68,6%(n=24).The most commonly used chemotherapeutic agent was Paclitaxel.In our sample,median time to recurrence was 29.6 months. 51,4%(n=18) suffered a recurrence and 25,7%(n=9) progressed after intervention.Regarding current status,45,7%(n=16) live without disease,28,6% (n=10) live with disease and 25,7%(n=9) died because of the disease. Complete citoreduction (R0) was achived in 45,7%(n=16),being 31,4%(n=11) R1,and 20%(n=7) R2. 23 complications (65,7% of the sample)were recorded. All of them were classified by systems and gravity(major and minor).Regarding major complications,13.04%(n=3) were due to intestinal injury during surgery,8.7%(n=2) were bladder injury,4.35%(n=1) ureteral injury and 21.74%(n=5) of them were due to blood loss(>1L),which required blood transfusion.It is noteworthy that kidney failure rate is 0% in our sample.In relation to minor complications,13.04% correspond to fever without a focus,8.7% to infection of the surgical wound(seromas).We only found 4 complications Clavien-Dindo IIIa, 2 IIIB and 1 IV. In the sample, the average ICU stay is 1.3 days.The average hospital stay was 7.6 days.

Conclusion Despite the radicality of the surgical procedures performed, toxicity was mild and major complications were rare and successfully resolved.In our study there have been no complications resulting in death.