Introduction/Background Malignant Brenner tumors (MBT) of the ovary are rare disease; representing 1. 5% of all ovarian cancers and 3. 5% of Brenner tumors. They carry a poor prognosis. They generally affect women during the perimenopausal and postmenopausal periods. The aim of this study is to report our experience in the treatment of MBT of the ovary, to better characterize this disease.

Methodology A retrospective case series involving 5 patients diagnosed with MBT of the ovary and treated between 2006 and 2020.

Results The mean age of our patients was 54. 1 years. Four patients were in the menopause period. The tumor was staged as IC in one case, IIC in one case and IIIC in three cases of FIGO classification. All women conducted surgery followed by adjuvant chemotherapy. Four patients underwent a loco-regional recurrence that occurred respectively after 9, 11 and 13 months in three patients. The treatment was based on chemotherapy, combined with surgery in one case. Two patients presented distant metastasis. The treatment consisted of chemotherapy and surgery. One patient of them died after surgery from massive pulmonary embolism. The mean follow up period was 39. 5 months.

Conclusion The treatment approach of MBT of the ovary is not well established since its scarcity and poor prognosis. Thus, more case series and meta-analysis should be conducted.