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2022-RA-1348-ESGO Role of computed tomography (CT) scan based reporting system ‘PAUSE’ to predict surgical resectability in epithelial ovarian cancer
  1. Seema Singhal1,
  2. Atul Sharma2,
  3. Ekta Dhamija3,
  4. Sunesh Kumar2,
  5. Jyoti Meena2,
  6. Rajesh Kumari2,
  7. Anju Singh2,
  8. Sarita Kumari2,
  9. Jayashree Natarajan4,
  10. Anu Sabarinath2,
  11. Amit Mandal2,
  12. Rudrika Chandra2,
  13. Romey Rai2,
  14. Dipanwita Banerjee2,
  15. Swati Tomar5,
  16. Sandeep Mathur6 and
  17. Neerja Bhatla2
  1. 1Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India
  2. 2Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India
  3. 3Radio diagnosis, All India Institute of Medical Sciences, New Delhi, India
  4. 4Gynecologic Oncology, Adyar cancer institute, Chennai, India
  5. 5All India Institute of Medical Sciences, New Delhi, India
  6. 6Pathology, All India Institute of Medical Sciences, New Delhi, India


Introduction/Background A novel ‘PAUSE’ reporting system was devised for standardization of reporting of CT based PCI in peritoneal malignancies and, also to emphasize increased focus on areas which often make the difference between optimal and suboptimal cytoreduction. The aims of current study were to evaluate the efficacy of CT scan-based protocol i.e. ‘PAUSE’, in predicting the optimal and suboptimal cytoreduction in EOC, and also to assess the role of intraoperative use of telescope to improve surgical PCI.

Methodology A prospective observational pilot study recruited 30 women with EOC undergoing primary debulking surgery. The CECT was evaluated in accordance with the ‘PAUSE’ protocol to assess resectability. Surgical PCI was calculated before surgery and was revised using intraoperative telescope. Agreement was done using kappa statistics and Bland-Altman agreement analysis.

Results The agreement between CT-PCI and surgical PCI was of low degree. Higher CT-PCI scores correlated with suboptimal resection; disease in regions 1, 3, 9, 10, 11 and 12 was more predictive of surgical outcome. The overall sensitivity, specificity, PPV and NPV of PAUSE with regards to prediction of surgical resectability was 81.3%, 35.7%, 59.1% and 62.5%, respectively. Diagnostic accuracy of PAUSE was 60%. Amongst the components, the maximum accuracy to predict sub optimal CRS was of U1 lesions, small bowel and mesentery involvement (66.7%), followed by U2 and A (53.3% and 50% respectively). New lesions were identified in 6 (20%) patients in subdiaphragmatic areas and the lesser sac using intra operative telescope in open surgery.

Conclusion ‘PAUSE’ did not show statistical significance with surgical outcome with modest diagnostic accuracy. Most useful parameters for prediction of surgical resectability, were the presence of U1/U2 lesions and the involvement of small intestine and mesentery; Presence of ascites (A component) was least predictive; thus, should not be used as a sole criterion.

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