Introduction/Background While obesity is associated with a higher risk of mortality in several cancers, this relationship is equivocal in ovarian cancer. Some studies show a significant impact of this comorbidity on both incidence and survival. However, other studies do not show a significant difference in survival and recurrence-free survival. The primary objective of our study is to investigate the impact of obesity in the management of patients with FIGO III or IV high-grade serous epithelial ovarian cancer. Secondary objectives include evaluation of postoperative complications, number of patients treated according to the referral, and analysis of survival data

Methodology Retrospective multicenter cohort study of epithelial ovarian cancer from the FRANCOGYN database. The inclusion criterion is surgical management of high-grade invasive epithelial ovarian cancer, FIGO stage III or IV, regardless of treatment strategy. All patient characteristics will be analyzed as risk factors for the development of postoperative complications and adjuvant treatments. Patients were stratified by body mass index (BMI) according to World Health Organization definitions into 3 groups (<25 kg/m2, between 25 and 29.9 kg/m2, and >30 kg/m2). Surgical procedures and intraoperative complications were studied. Comparison of group characteristics will be performed using Chi-2 Test and ANOVA, and survival analysis will be performed using Kaplan-Meier method and Log-Rank test.

Results A total of 2288 patients were included in the study. Regarding disease-free survival, there was no significant difference between the 3 groups(p=0.3). However, there was a lower overall survival in the obese group compared to overweight patients with a normal BMI(p=0.02). There was no significant difference regarding the operative time nor regarding the per- and postoperative complications.

Conclusion There is an impact of obesity on overall survival in patients with epithelial ovarian cancer, and the initial treatment strategy remains unchanged in these patients with a high BMI.