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2022-RA-1119-ESGO Burdened family history in patients with ovarian cancer: retrospective monocentric study
  1. Hanna Trukhan1,
  2. Yuliya Lufiarova Lufiarova2,
  3. Volha Ramanovich3,
  4. Sergey Mavrichev4 and
  5. Elena Dalamanava5
  1. 1Oncologic Department, Belarussian Medical Academy of Postgraduate Education, Minsk, Belarus
  2. 2Genetics Laboratory, National Molecular Genetics Laboratory of Cancer Research, p.Lesnoy, Belarus
  3. 3Cancer Control Department, NN Alexandrov National Cancer Centre of Belarus, p. Lesnoy, Belarus
  4. 4NN Alexandrov National Cancer Centre of Belarus, p.Lesnoy, Belarus
  5. 5Oncogynecologic Department, NN Alexandrov National Cancer Centre of Belarus, p.Lesnoy, Belarus


Introduction/Background It`s very important to identify individuals with high genetic risk of developing cancer for prevention of familial ovarian cancer forms, their follow-up management and timely preventive care. A burdened family history (BFH) of cancer is unquestionable and most important indication for genetic testing. Objective: To assess the BFH in patients with ovarian cancer (OC), fallopian tube carcinoma (FTC), primary peritoneal carcinoma (PPC).

Methodology All women with OC, FTC and PPC, who treated at oncogynecologic department N.N. Alexandrov National Cancer Centre of Belarus between January 2022 and May 2022 were retrospectively identified. The main criteria were serous carcinoma, endometrioid carcinoma and clear cell carcinoma. All patients filled out BFH questionnaires. Analysis of the normality of data distribution was carried out on the basis of the Shapiro-Wilk’s W test. The Mann-Whitney U-test was used to compare two independent samples.

Results A total of 92 patients were analyzed: 81 patients with OC, 9 with FTC, 2 with PPC. The mean was 54.5 years, high grade serous carcinoma was the predominant (87%). The majority of patients were of Belarusian (93.5%). 53 (57.6%) women were in menopause at the time of diagnosis, in premenopause was less (28.3%). Most of the study participants had pregnancies, children, lactation were noted (88.0%, 84.8%, 71.7%, respectively). Only 15.2% of women indicated the use of contraceptives. A BFH was noted in 58 (63.0%) patients, it was absent in 34 (17%) patients. The average age of women with a BFH was 53.2 years, without – 56.7 years. There were no statistically significant differences in the groups of patients without and with a BFH, depending on age, diagnosis, histological variant of the tumor (p>0.05).

Conclusion Presence of burdened family history revealed in most cases (63% patients with OC, FTC, PPC) requires further genetic testing.

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