Introduction/Background Introduction The treatment of recurrent ovarian cancer (ROC) confronts us with major clinical and social problems. However, the question of how to appropriately manage vulnerable, elderly or multimorbid patients in the palliative setting is of key importance. It should be borne in mind that elderly or heavily pretreated patients in particular may suffer from a range of comorbidities and persistent toxicities from previous therapies. Nevertheless, chronological age cannot be the only factor used to make treatment decisions. The evaluation of organ function, cognitive, emotional factors and social behaviour all have an equal impact on the patient‘s well-being and can be used as prognostic factors. However, clinical experience and practical implementation in gynaecological oncology are largely lacking in this regard. Therefore, it is important if innovative predictive models can be developed and implemented into the clinical routine.

Methodology Rationale and Objective The aim of this observational study is, first, to prospectively evaluate the practical impact of scientific-based geriatric, psychological and functional assessments based on mental, emotional, disease-related and patient-reported outcome measures (PROM), as well as to assess clinicopathological and disease-related variables. Based on this evidence, a predictive score will be developed. In a second stage of the study, we also plan to evaluate its predictive power to identify those fragile patients who will interrupt or discontinue recurrent chemotherapy within the first 12 weeks of therapy.

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