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  • 2022-RA-589-ESGO The effect of major postoperative complications on recurrence and long-term survival after cytoreductive surgery for ovarian cancer

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Ovarian cancer
2022-RA-589-ESGO The effect of major postoperative complications on recurrence and long-term survival after cytoreductive surgery for ovarian cancer
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  1. Martina Aida Angeles1,
  2. Alicia Hernández2,
  3. Asunción Pérez-Benavente3,
  4. Bastien Cabarrou4,
  5. Emanuela Spagnolo2,
  6. Agnieszka Rychlik5,
  7. Amel Daboussi6,
  8. Federico Migliorelli7,
  9. Sarah Bétrian8,
  10. Gwénaël Ferron1,
  11. Antonio Gil-Moreno3,
  12. Frédéric Guyon9 and
  13. Alejandra Martinez1
  1. 1Department of Surgical Oncology, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, France
  2. 2Hospital La Paz, Madrid, Spain
  3. 3Hospital Vall d’Hebron, Barcelona, Spain
  4. 4Biostatistics Unit, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, Spain
  5. 5Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland
  6. 6Department of Anesthesiology, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, France
  7. 7Paule de Viguier Hospital, Toulouse University Hospital, Toulouse, France
  8. 8Department of Oncology, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, France
  9. 9Institut Bergonié, Bordeaux, France

Abstract

Introduction/Background To assess the impact on survival of major postoperative complications and to identify the factors associated with these complications in patients with advanced ovarian cancer after cytoreductive surgery.

Methodology We designed a retrospective multicenter study collecting data from patients with IIIC-IV FIGO Stage ovarian cancer who had undergone either primary debulking surgery (PDS), early interval debulking surgery (IDS) after 3–4 cycles of neoadjuvant chemotherapy, or delayed debulking surgery (DDS) after 6 cycles, with minimal or no residual disease, from January 2008 to December 2015. Univariable and multivariable analyses were conducted to identify factors associated with major surgical complications (≥Grade 3). We assessed disease-free survival (DFS) and overall survival (OS) rates according to the occurrence of major postoperative complications.

Results 549 women were included. The overall rate of major surgical complications was 22.4%. Patients who underwent PDS had a higher rate of major complications (28.6%) than patients who underwent either early IDS (23.2%) or DDS (14.0%). Multivariable analysis revealed that extensive peritonectomy and surgical timing were associated with the occurrence of major complications. Median DFS and OS were 16.9 months (95%CI=[13.7–18.4]) and 48.0 months (95%CI=[37.2–73.1]) for the group of patients with major complications, and 20.1 months (95%CI=[18.6–22.4]) and 56.7 months (95%CI=[51.2–70.4]) for the group without major complications. Multivariable analysis revealed that major surgical complications were significantly associated with DFS, but not with OS.

Abstract 2022-RA-589-ESGO Figure 1
Abstract 2022-RA-589-ESGO Figure 1

Disease-free survival (A) and overall survival (B) curves according to the occurrence of major post-operative complications

Abstract 2022-RA-589-ESGO Figure 2
Abstract 2022-RA-589-ESGO Figure 2

Disease-free survival (DFS) and overall survival (OS) curves according to the occurrence of major post-operative complications in the group of patients with primary debulking surgery (C and D); and delayed debulking surgery (E and F)

Conclusion Patients who experienced major surgical complications had reduced DFS, compared with patients without major morbidity. Extensive peritonectomy and surgical timing were predictive factors of postoperative morbidity.

https://doi.org/10.1136/ijgc-2022-ESGO.519

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