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2022-RA-1639-ESGO Management of primary & secondary breast lymphoma
  1. Amani Jellali,
  2. Ines Zemni,
  3. Takoua Chalouati,
  4. Sarra Ben Ltaief,
  5. Fatma Saadallah,
  6. Riadh Chargui and
  7. Khaled Rahal
  1. Department of surgical oncology, Salah Azaiez Institute, Tunisia, Tunisia


Introduction/Background Breast lymphomas are extremely rare malignancies in both genders, especially in men. They can be either primary or secondary. Primary ones are malignant lymphomas that occur in the breast without previously detected lymphomas. Their reported incidence is 0.04% of all breast malignancies.We aimed to discuss the clinical aspect, the anatomopathological characteristic, and the evolution of this rare entity.

Methodology We report seven cases of breast lymphomas followed up at Salah Azaiez institute of oncology in Tunis.

Results The median age at the diagnosis of breast lymphoma was 49 years. Six patients were female. The mean tumor size was 33 mm. inflammatory breast tumor was noticed in one case, while six patients presented a palpable mass. Breast imaging revealed suspicious lesions classified as BIRADS 5 in all cases. Microbiopsy was performed in all cases. Secondary lymphoma was found in six patients (3 high-grade B cell lymphomas, 3 Hodgkin lymphomas), while primary one was noted in a male breast patient. Neoadjuvant chemotherapy followed by a modified radical mastectomy was performed in one case. 6 patients had chemotherapy. Two of them had 2 years of follow-up with no sign of recurrence. One patient had local recurrence. The rest of patients were lost of follow-up.

Conclusion There is no therapeutic consensus because of the rarity and heterogeneity of primary breast lymphomas. Treatment for breast lymphoma is based upon the overall staging of the lymphoma and generally requires chemotherapy, surgery, and radiation therapy.

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