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2022-RA-1567-ESGO Papillary breast carcinoma: clinicopathological characteristics & prognosis
  1. Saida Sakhri,
  2. Takoua Chalouati,
  3. Malek Bouhani,
  4. Amani Jellali,
  5. Maher Slimane and
  6. Khaled Rahal
  1. Surgical oncology department, Salah Azaiez institute, Tunis, Tunisia


Introduction/Background Breast cancer is the most prevalent type of cancer in women. Invasive papillary carcinoma (IPC) is a rare pathological type that accounts for around 3% to 6% of all invasive breast cancers. It is linked to an increased risk of axillary lymph node metastases and lymphovascular invasion. Local recurrence seems to be more frequent.

Methodology Data of 70 patients were reviewed retrospectively. Thirty of them were included in our study between 2004 and 2022,

Results All of the patients were female, with a mean age of 62. The right breast was the most affected. The tumor was largely situated in the outerupper quadrant. In 76 percent of cases, a breast lump and an axillary lymph node were found, with 20 percent of cases being metastatic. The tumor was classified as T2N1M0 in 50% of cases. ultrasound examination showed a cystic or solidocystic appearance In the majority of cases. The mean histological tumor size was 26 mm. Immunohistochemical studies revealed the positivity of hormonal receptor in 73% and the negativity of HER in all cases. Age, lymphovascular invasion, and tumor necrosis were all significantly correlated to the recurrence-free and overall survival. Local recurrence was observed in 6% of patients. Five-year recurrence-free survival and overall survival rates were 87 and 88 percent, respectively.

Conclusion IPC is characterized by aggressive clinicopathologic features. Their prognosis is thouht to be poorer than other breast malignancies such as invasive ductal carcinoma. However our study showed high rates of survival and low incidence of recurrence

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