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2022-RA-171-ESGO Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer
  1. Giorgio Bogani1,
  2. Violante Di Donato2,
  3. Giovanni Scambia3,
  4. Pierluigi Benedetti Panici2,
  5. Fabio Landoni4,
  6. Francesco Raspagliesi5,
  7. The Italian Gynecologic Oncology group
  1. 1Gynecologic Oncology, La Sapienza of Rome, Rome, Italy
  2. 2University La Sapienza, Rome, Italy
  3. 3Policlinico Gemelli, Rome, Italy
  4. 4Università Bicocca – Policlinico di Monza, Monza, Italy
  5. 5Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy


Introduction/Background To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer.

Methodology This is a retrospective, multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial.

Results Charts of 1,295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial the number of patients treated with minimally-invasive radical hysterectomy decreased from 64.9% to 30.4% (p<0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in period I and period II, respectively (p=0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p=0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p=0.471), IB1 (p=0.929), and IB2 (p=0.074), separately.

Conclusion The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influenced 90-day surgery-related morbidity.

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