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2022-RA-1599-ESGO Pregnancy associated breast cancer: about 10 cases
  1. Amal Chermiti,
  2. Hajer Bettaieb,
  3. Rahma Bouhmida,
  4. Nesrine Souayeh,
  5. Meriem Ouederni,
  6. Hadir Lamiri,
  7. Mohamed Frikha,
  8. Wael Mbarki,
  9. Hadhami Rouiss,
  10. Hedhili Oueslati and
  11. Chaouki Mbarki
  1. Gynecology and obstetrics, Regional hospital ben Arous Tunisia, Tunis, Tunisia


Introduction/Background Pregnancy-associated breast cancer (PABC) is defined as breast cancer diagnosed during pregnancy or in the first postpartum year. While it is relatively uncommon (occurring in 1 per 3000 pregnancies), it represents a challenge to both the patient and the multidisciplinary team.we ought in this study to describe, the clinical, paraclinical and management of pregnancy associated breast cancer.

Methodology we conducted a retrospective single-center cohort study of 10 patients diagnosed and treated for breast cancer during pregnancy between 2005 and 2022 in the obstetric and gynecology department of Ben Arous hospital.

Results Five patients were diagnosed during the second trimester, 3 during the first trimester and 2 in the postpartum period. A suspicious area was detected by ultrasound in 10 of 15 women. A recurrent abscess was present in 2 cases and the biopsy revealed the cancer. Five patients had positive hormone receptors and 7 sub expressed. One patient was in stage 0, 2 in stage 1, 2 in stage 3 and 5 in stage 4. Three patients decided voluntarily to legally terminate their pregnancies. Seven patients were treated with chemotherapy during pregnancy after the second trimester using anthracycline-based treatment. Three patients had gestation-related complications including preterm labor, intrauterine growth restriction dyspnea and chemotherapy related granulocytopenia.

Conclusion pregnancy associated breast cancer is a rare entity. It is associated with a high number of complications. A multidisciplinary approach is needed and patients should be an integral part of therapeutic decisions.

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