Vulvar cancer is rare, and unresectable disease provides a therapeutic conundrum. Although definitive surgery remains the mainstay for curative treatment of vulvar cancer, a minority of patients present with advanced disease for which surgical resection would be extraordinarily morbid. Pre-operative and definitive radiation with radiosensitizing systemic therapy allows such patients an opportunity for cure. In this review, we explore the origins of pre-operative radiation, current treatment standards for pre-operative and definitive chemoradiation, and future directions.
- vulvar and vaginal cancer
- radiation oncology
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Contributors PNB, DCL, and SB contributed equally to the planning, writing and development of this review article.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests SB: Elsevier pathway consultant; Xoft DSMBVarian employer. PNB: Elsevier pathway consultant. DCL: None.
Provenance and peer review Commissioned; internally peer reviewed.