Objectives The prevalence of Endometrial Cancer (EC) progressively increases with age, therefore, with the general aging of the population, we will have to treat a rising number of patients defined as ‘elderly’. The main study goal was to assess the overall detection rate, the bilateral mapping, and the mapping failure rate in elderly patients, and to evaluate SLN anatomical distribution and predictors for mapping failure.
Methods A cohort of patients with apparently early-stage EC undergoing SLN biopsy between May-2015 and March-2021, in 4 Italian referral Cancer-Center, were retrospectively retrieved. The study population has been divided into women under and over 65 (Group-1 and 2).
Results Eight-hundred-forty-four women were enrolled (group 1: 449, group 2: 395). A 1.280-fold increase in the risk of failed mapping per 10-year-old increase (OR: 1.280, p=0.001) and a decrease of both overall detection rate and bilateral mapping were found (respectively OR: 0.726, p=0.006 and OR 0.781, p=0.001) (figure 1). A decreased SLN mapping along the ‘uncommon sites’ was noted in older women (left hemiplevis: 15.7% vs 7, 1%, p <0.001; right hemiplevis 13.2% vs 8.6%, p =0.058) (figure 2).
Conclusions Age represented an independent predictor of unsuccessful mapping and affects the anatomical distribution of the SLN leading to a stepwise reduction of ‘uncommon’ mapping sites.
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