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EPV138/#609 Sentinel lymph-node in aged endometrial cancer patients ‘the sage study’: a multicenter experience
  1. A Rosati1,
  2. S Cianci2,
  3. V Vargiu3,
  4. VA Capozzi4,
  5. G Sozzi5,
  6. R Berretta4,
  7. F Cosentino6,
  8. S Gueli Alletti1,
  9. A Ercoli2,
  10. V Chiantera5,
  11. G Scambia1 and
  12. F Fanfani1
  1. 1Università Cattolica del Sacro Cuore, Department of Woman and Child Health and Public Health, Woman Health Area, Fondazione Policlinico Universitario A. Gemelli Irccs, Roma, Italy
  2. 2Università degli Studi di Messina, Policlinico G. Martino, Division of Gynecologic Oncology, Messina, Italy
  3. 3Gemelli Molise SpA, Ginecologia Oncologica, Campobasso, Italy
  4. 4University of Parma, Department of Medicine and Surgery, Parma, Italy
  5. 5University of Palermo, Department of Gynecologic Oncology, Arnas Civico Di Cristina Benfratelli, Palermo, Italy
  6. 6Gemelli-Molise, Università Cattolica del Sacro Cuore, Division of Gynecologic Oncology, Campobasso, Italy


Objectives The prevalence of Endometrial Cancer (EC) progressively increases with age, therefore, with the general aging of the population, we will have to treat a rising number of patients defined as ‘elderly’. The main study goal was to assess the overall detection rate, the bilateral mapping, and the mapping failure rate in elderly patients, and to evaluate SLN anatomical distribution and predictors for mapping failure.

Methods A cohort of patients with apparently early-stage EC undergoing SLN biopsy between May-2015 and March-2021, in 4 Italian referral Cancer-Center, were retrospectively retrieved. The study population has been divided into women under and over 65 (Group-1 and 2).

Results Eight-hundred-forty-four women were enrolled (group 1: 449, group 2: 395). A 1.280-fold increase in the risk of failed mapping per 10-year-old increase (OR: 1.280, p=0.001) and a decrease of both overall detection rate and bilateral mapping were found (respectively OR: 0.726, p=0.006 and OR 0.781, p=0.001) (figure 1). A decreased SLN mapping along the ‘uncommon sites’ was noted in older women (left hemiplevis: 15.7% vs 7, 1%, p <0.001; right hemiplevis 13.2% vs 8.6%, p =0.058) (figure 2).

Abstract EPV138/#609 Figure 1

Bionominal logistic regression analysis for 10 year age increaseUnivariate analysis per 10 year age increaseMapping failure risk: OR: 1.280 (95% CI: 1.108-1.479, p=0.001)Overall detection rate: OR 0.726 (95% CI: 0.577-0.913, p=0.006)Successful maping rate: OR 0.781 (95% CI: 0.676-0.902, p=0.001)

Abstract EPV138/#609 Figure 2

Anatomical localizations of sentinel lymph nodes

Conclusions Age represented an independent predictor of unsuccessful mapping and affects the anatomical distribution of the SLN leading to a stepwise reduction of ‘uncommon’ mapping sites.

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