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EPV134/#557 The study of some clinico-genetic characteristics in pregnant women with uterine leiomyomas
  1. J Ungiadze1,
  2. N Zamtaradze1,
  3. K Samnidze2,
  4. D Ungiadze3 and
  5. I Nakashidze1
  1. 1Batumi Shota Rustaveli State University, Department of Clinical Medicine, Batumi, Georgia
  2. 2Medina, Department of Gynecology, Batumi, Georgia
  3. 3Tbilisi State Medical University, Department of Clinical Medicine, Tbilisi, Georgia


Objectives Uterine leiomyomas (ULs) are common among pregnant women. Besides numerous investigations, the relationship between ULs and adverse pregnancy outcome is not clearly understood until now. Notably, the majority of fibroids do not change their size during pregnancy, but one-third may grow in the first trimester, also may cause multiple complications

Methods We evaluated some clinical variables, including the following: the patient age, the size and number of uterine fibroids, serum levels of Anti-TPO, Ft4, TSH, Glucose, Antiphospholipid Antibodies and Ferritin. Also, we investigated the fetus risk for trisomies of 13, 18, and 21 chromosomes. In present study, we included 20 pregnant women (10 with leiomyomas (ages - 37± 2,334) and 10 without leiomyomas (ages - 38 ± 3,44)). P < 0.05 was regarded as statistically significant.

Results Our study suggested that ULs are associated with hypothyroidism in pregnant women with ULs. Notably, our studies show that all fetuses are non-affected, according to trisomies.

Conclusions In conclusion, we have thought that the hypothyroidism may some role in ULs.

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