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EPV118/#381 The increased incidence of uterine cancer with high risk histologies – a population study from the Taiwan cancer registry
  1. C-I Liao1,
  2. M Richardson2,
  3. C Tian3,
  4. K Darcy3,
  5. D Kapp4 and
  6. J Chan5
  1. 1Kaohsiung Veterans General Hospital, Obstetrics and Gynecology, Kaohsiung City, Taiwan
  2. 2University of California, Los Angeles, Obstetrics and Gynecology, Los Angeles, USA
  3. 3Gynecologic Cancer Center of Excellence, Obstetrics and Gynecology, Washington, USA
  4. 4Stanford University School of Medicine, Department of Radiation Oncology, Stanford, USA
  5. 5California Pacific Medical Center, Obstetrics and Gynecology, San Francisco, USA


Objectives To evaluate trends in uterine cancer diagnosis and incidence by histology in Taiwan between 2001–2017.

Methods Data were obtained from the Taiwan Cancer Registry of Taiwan Health and Welfare Data Center for women diagnosed with a malignancy of the uterine corpus from 2001 to 2017. Joinpoint regression analysis was used to evaluate and project trends over time.

Results There were 26,827 women in Taiwan Cancer Registry diagnosed with uterine cancer between 2001–2017, including 25.2% with grade (G)1-endometrioid endometrial carcinoma (EEC), 36.5% with G2-EEC, 25.2% G3-EEC, 3.5% with uterine serous carcinoma (USC), 3.4% with uterine carcinosarcoma (UCS) and 2.1% with uterine clear cell carcinoma (UCCC). The proportion of women with a high-risk histology defined as G2-EEC, G3-EEC, USC, UCS, or UCCC increased from 51% to 63% when diagnosed at 50–59 or 60–69 years of age, respectively. The average incidence per 100,000 by histology was 9.2 with EEC, 0.64 with USC, 0.51 with UCS, and 0.25 with UCCC. The annual percent change (APC) in incidence between 2001 and 2017 increased by 10.6% for a USC diagnosis, 5.8% for a UCS diagnosis, and 4.6% for a UCCC diagnosis. Predictive modeling projects that the incidence of USC in women between 60–64 years old will surpass G1-EEC incidence in the same age group by 2022.

Conclusions High-risk uterine cancers constitute a substantial portion of the uterine cancers in the Taiwan Cancer Registry, particularly for women in their 60s or older. This exponential rise has important health and welfare implications in Taiwan and the International community.

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