Article Text

Download PDFPDF

EPV113/#323 Prognostic factors and oncologic outcomes for patients treated with adjuvant chemotherapy and vaginal vault brachytherapy for stage I endometrial serous carcinomas
  1. V Dorion1,
  2. V Samouëlian2,
  3. M-C Beauchemin1,
  4. B Cormier2,
  5. E Tremblay2 and
  6. M Barkati1
  1. 1Centre hospitalier de l’Université de Montréal, Radiation Oncology, Montreal, Canada
  2. 2Gynecologic Oncology Service, CHUM, Université de Montréal, Department of Obstetrics and Gynecology, Montreal, Canada


Objectives Endometrial serous carcinomas (ESC) hold a poor prognosis, even at early stages. This study evaluates the outcomes and prognostic factors for stage I (FIGO 2018) ESC treated with adjuvant chemotherapy and vaginal vault brachytherapy (VBT).

Methods Patients were selected through a database of patients treated with hysterectomy for stage I ESC between 2007 and 2019 at the Centre Hospitalier de l’Université de Montréal. The intended adjuvant treatment had to be 6 cycles of Carboblatin and Paclitaxel and VBT. Time to events were analyzed by Kaplan-Meier. Cox regression analysis was performed to identify prognostic factors.

Results A total of 76 patients with stage IA (N=64) and IB (N=12) ESC were included in this study. Median age at diagnostic was 67. Median follow up was 60 months. 5-year overall survival (OS) and progression-free survival (PFS) were 83% and 79.5%. Nine patients relapsed, 3 with local recurrence, 3 with regional recurrence and the other 3 with distant recurrence. Amongst the known prognostic factors included in univariate analysis, positive peritoneal washing and advanced age were significant prognostic factors for OS (p<0.0001 and p=0.013, respectively). Age, isthmus invasion, deep myometrial invasion and positive peritoneal washings were significant prognostic factors for PFS (p=0.049, p=0.024, p=0.022 and p<0.0001, respectively).

Conclusions In stage I ESC, adjuvant chemotherapy and VBT was associated with good oncologic outcomes. Advanced age and positive peritoneal washings were significant prognostic factors for OS. Further studies are needed to assess whether a subgroup of patients would benefit from treatment intensification or de-escalation.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.