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EPV111/#303 Sentinel lymph node mapping for endometrial cancer: a prospective study about thirty eight cases
  1. S Sghaier1,
  2. H Bouaziz2,
  3. N Tounsi3,
  4. M Bouhani2,
  5. L Zaabar4,
  6. G Sahraoui5,
  7. H Bouzainne2,
  8. M Slimane2 and
  9. K Rahal2
  1. 1Salah Azaiez Institute, Surgical Oncology Department, Tunis, Tunisia
  2. 2Salah Azaiez Institute of Oncology, Surgical Oncology, Tunis, Tunisia
  3. 3salah Azaiz Institut, Department of Surgical Oncologists, Tunis, Tunisia
  4. 4Salah Azaiez Institute, Nuclear Medicine, Tunis, Tunisia
  5. 5Salah Azaiez Institute, Anatomopathology, Tunis, Tunisia


Objectives Endometrial cancer (EC) represents the most common gynecological cancer mostly diagnosed at stage I. Sentinel lymph node (SLN) arised as a valuable option to lymph node dissection. We aim to determine negative predictive value (NPV),overall and bilateral detection rates of SLN in EC stage I.

Methods This was a cross-sectional prospective study including 38 patients with EC stage I treated at Salah Azaiz Institute over a period of 34 months from March 2018 to January 2021.

Results Endometrioid adenocarcinoma was reported in 89% of cases. The pelvic MRI showed IA and IB stages in 58% and 42% of cases, respectively.The detection techniques were combined (48%), colorimetric (34%) and radioisotope (18%). Lymphoscintigraphy was conducted in 66% of women demonstrating overall, bilateral and failed detection rates of 92%, 24% and 8%, respectively. The overall, bilateral and failed intra-operative detection rates were of 76%, 37% and 24% respectively. A micrometastasis (1%) was noted among a total of 87 SLNs. False negative rate (FNR) and NPV were of 0% and 100%.Factors affecting overall detection wereinitial histologic grade (p=0.01) and tumor size on MRI (p=0.04). Final histologic grade 1 (p=0.005), 2 (p=0.002) and myometrial invasion (p=0.04) were also significant contributors.No significant factors affecting bilateral detection were set.

Conclusions FNR and NPV were of 0% and 100% similarly to previous results through literature. We aim to continue this promising protocol toward including more patients that may helps us improve our overall and bilateral detection rates.

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