Objectives HLA-G gene polymorphisms have been linked to many cancers particularly to cervical squamous cell carcinoma (CSCC). In this meta-analysis, we studied the association of HLA-G +3142 C/G and 14bp Insertion/deletion (Ins/Del) polymorphisms with cervical pathologies susceptibility.
Methods A comprehensive systematic literature search in Medline, Pubmed, Cochrane, Embase, and Web of Science databases was performed to look up relevant studies. We identified four studies for HLA-G +3142 C/G (299 patients with HPV+ high-risk cervical pathologies and 870 healthy controls (HC)); and six studies for HLA-G14bp Ins/Del (693 patients with HPV+ high-risk cervical pathologies and 2536 HC). The association was studied through the calculation of the odds ratio (OR) and the corresponding 95% confidence interval (CI).
Results HLA-G +3142 C/G polymorphism and HLA-G 14 bp Ins/Del significantly enhanced the risk for HPV+ cervical pathologies only in Asians conversely to overall population and Caucasians. HLA-G +3142 C/G enhanced the HPV+ high-risk cervical pathologies risk under allelic C vs. G model (OR=1.321, 95CI%=1.035–1.686, p=0.025) and under the genotypic model CC vs. GG+GC (OR=2.028, 95CI%=1.337–3.075, p=0.001). HLA-G 14bp Ins/Del increased also the HPV+ cervical pathologies risk only under the genetic model (InsIns vs. DelDel+InsDel) (OR=1.910, 95%CI=1.151–3.171, p=0.012) in Asians.
Conclusions Our preliminary meta-analysis showed a significant association of HLA-G +3142 C/G polymorphism and HLA-G 14bp Ins/Del with HPV+ high-risk cervical pathologies susceptibility in Asians. Further studies still needed in other ethnicities to clearly establish our findings.
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