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EPV043/#200 The increasing incidence of metastatic cervical cancer in the United States – what factors are responsible?
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  1. C-I Liao1,
  2. A Francoeur2,
  3. A Milki3,
  4. E Thayer4,
  5. A Mann5,
  6. MA Caesar6,
  7. A Chan7,
  8. B Monk8,
  9. D Kapp9 and
  10. J Chan10
  1. 1Kaohsiung Veterans General Hospital, Obstetrics and Gynecology, Kaohsiung City, Taiwan
  2. 2University of California Los Angeles, Obstetrics and Gynecology, Los Angeles, USA
  3. 3George Washington University School of Medicine and Health Sciences, Obstetrics and Gynecology, Washington DC, USA
  4. 4University of Massachusetts Medical School, Obstetrics and Gynecology, Worcester, USA
  5. 5Palo Alto Medical Foundation, Research Institute, Palo Alto, USA
  6. 6California Pacific Medical Center, Research Institute, San Francisco, USA
  7. 7Palo Alto Medical Foundation Research Intitute, Obstetrics and Gynecology, Palo Alto, USA
  8. 8Arizona Oncology, Gynecologic Oncology, Obstetrics and Gynecology, Phoenix, USA
  9. 9Stanford University School of Medicine, Department of Radiation Oncology, Stanford, USA
  10. 10California Pacific Medical Center, Obstetrics and Gynecology, San Francisco, USA

Abstract

Objectives To determine the incidence and trends of advanced stage cervical cancer in the United States.

Methods Data were obtained from the U.S. Cancer Statistics program from 2001–2017. SEER*Stat 8.3.8 and Joinpoint regression program 4.8.0.1 were used to calculate incidence trends.

Results of 27,102 patients with advanced stage cervical cancer from 2001–2017, 17,097 (63%) were White, 4,939 (5%) were Black, 3,636 were Hispanic (2%), and 1,117 were Asian (0.5%). Over time, there has been an annual increase in advanced stage cervical cancer at a rate of nearly 2% per year (p<0.001); however, those with early stage cancers have a decrease of 1.54% annually (p<0.001). Women aged 30 to 65 years showed an overall increase in incidence, however those 30–34 years olds have a particularly high increase at 3.39% annually (p<0.001). Although the overall incidence of advanced cancers is higher in Hispanic and Black populations, there is an increasing number of new cases in White women at 2.39% annually (p<0.001). Compared to other groups, the intersection of White women aged 40–44 in the South have the highest average annual increase at 5.07% (p<0.001).

Conclusions Although the overall incidence of advanced cervical cancers is highest in Hispanic and Black women, there is an increase in incidence in White women particularly in the Southern region of the U.S. More research is needed to understand this trend particularly in relation to screening and treatment of precancerous disease.

https://doi.org/10.1136/ijgc-2021-IGCS.111

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