Objectives Paget’s disease is an uncommon breast malignancy and often misdiagnosed, it is associated with underlying in situ or invasive breast cancer. The objective of this study is to identify the type of underlying cancer and specify these characteristics.
Methods Nine patients with Paget’s disease who were admitted to our hospital were analyzed retrospectively.
Results Our study included nine patients. Six patients were menopaused. Only seven patients presented with clinical findings suggestive of Paget’s disease of the breast. The mean size of the tumor was 36mm and axillary lymph node were found in seven cases and Mammography and ultrasonography were was performed in all 16 patients and ultrasonography,of the nine mammographic studies, three were negative, in the others cases it showed suspected opacity in three cases, pleomorphic microcalcifications in four cases and both opacity and microcalcifications in three cases.Four patients had multifocality or multicentricity. Modified radical mastectomy was performed in seven patients, mastectomy and sentinel lymph node dissection in two cases in two, and wide local excision with lymph node dissection in one patient. Pathological findings were ductal carcinoma in situ (DCIS) (n = 4), invasive ductal carcinoma (IDC) (n = 1), invasive lobular carcinoma (n = 1), DCIS with IDC (n=4). All tumors had a high nuclear grad.
Conclusions Patients with Paget’s disease of the breast have a high incidence of an underlying breast carcinoma. Most of the patients in this study presented late and were more likely to have positive mammograms.
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