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EPV017/#299 Phyllodes tumors of the breast: a retrospective analysis of clinicopathological features of local recurrence
  1. H Bouaziz1,
  2. N Tounsi2,
  3. S Jouini2,
  4. S Sakhri2,
  5. S Yahiaoui3,
  6. S Kammoun4 and
  7. K Rahal2
  1. 1Salah Azaiez Institute of Oncology, Surgical Oncology, Tunis, Tunisia
  2. 2Salah Azaiez Institute of Oncology, Surgical Oncology, Tunis, Tunisia
  3. 3Salah Azaiez Institute of Oncology, Radiotherapy, Tunis, Tunisia
  4. 4Salah Azaiez Institute of Oncology, Department of Pathology, Tunis, Tunisia


Objectives Phyllodes tumors are biphasic tumors consisting of epithelial and stromal components that account for less than 1% of all breast tumors.

Methods Forty-one cases of phyllodes tumor (borderline and phyllode sarcoma) diagnosed between (2010–2018) were retrospectively studied. Cox proportional hazards regression models were used to analyze associations between clinicopathological features and disease recurrence P < 0.05 was considered significant.

Results From 41 tumors diagnosed 19 cases were classed as borderline (46.3%) and malignant phyllodes tumors in 22 cases (53.7%). Twenty-three (56.1%) were treated with mastectomy and 18 (43.9%) with conservative surgery. Seventeen (41.4%) of patient underwent adjuvant radiotherapy and three patients received chemotherapy. During a median follow-up of 80 months, LR rate was 12.2%, and 9.8% (p = 0.4) respectively in the borderline, and malignant groups. Young age (<35 years), presence of necrosis and positive surgical margin, severe stromal atypia, severe versus mild stromal cellularity, higher index mitosis was associated with increasing risk factor for LR. However only severe stromal cellularity was associated with significant prognostic factor (p: 0.005) in our study.

Conclusions Multiple histopathological features influence phyllodes recurrence.

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