Objectives BRCA1/2 are tumour-suppressor genes involved in DNA homologous recombination and ovarian cancer development.
Methods Risk-reducing surgery (RRS) was performed in 148 patients carrying BRCA1 (aged between 30–73 years, median age was 51 years) and BRCA 2 mutation (aged between 36–70 years, median age was 53 years). Seventy-nine patients had previous history of breast cancer.
Results Between the all patients, 131 women underwent risk-reducing salpingo-oophorectomy (RRSO) through a laparoscopic minimally invasive approach, 11 (7,4%) underwent laparoscopic RRSO and contextual hysterectomy, 2 woman (1,3%) underwent RRSO through a laparotomic approach and 12 women (8,1%) laparotomic RRSO and hysterectomy. During 7 (4,7%) laparoscopic RRSO, prophylactic bilateral mastectomy was also performed. Early and late complication occurred in 4 patients (3%). Six patients (4%) were found to have occult Serous Tubal Intraepithelial Carcinoma (STIC) and seven patients (4,7%) occult cancer.
Conclusions RRSO is safe and feasible in BRCA mutation carriers. The procedure is effective for genetic prevention of ovarian cancer.
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