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EPV245/#230 Increasing incidence of ovarian and uterine carcinosarcoma: a United States cancer statistics study
  1. I Tunnage1,
  2. C-I Liao2,
  3. D Lewis3,
  4. MA Caesar4,
  5. A Chan5,
  6. D Lee6,
  7. A Rohatgi5,
  8. K Darcy7,
  9. C Tian7,
  10. L Boyd1,
  11. D Kapp8 and
  12. J Chan9
  1. 1New York University, Gynecologic Oncology, New York, USA
  2. 2Kaohsiung Veterans General Hospital, Obstetrics and Gynecology, Kaohsiung City, Taiwan
  3. 3MedStar Washington Hospital Center, Obstetrics and Gynecology, Washington, USA
  4. 4California Pacific Medical Center, Research Institute, San Francisco, USA
  5. 5Palo Alto Medical Foundation Research Intitute, Obstetrics and Gynecology, Palo Alto, USA
  6. 6Palo Alto Medical Foundation, Research Institute, Palo Alto, USA
  7. 7Gynecologic Cancer Center of Excellence, Obstetrics and Gynecology, Washington, USA
  8. 8Stanford University School of Medicine, Department of Radiation Oncology, Stanford, USA
  9. 9California Pacific Medical Center, Obstetrics and Gynecology, San Francisco, USA


Objectives To identify trends in the incidence of ovarian and uterine carcinosarcoma.

Methods Data were obtained from the United States Cancer Statistics (USCS) Public Use Databases from 2001 to 2017. SEER*Stat 8.3.9, Joinpoint regression program, and Excel were used to calculate the incidence and trends. The age-adjusted incidence was calculated by WHO 2000 standard population.

Results In 2017, the incidence of ovarian and uterine carcinosarcoma was 0.25 and 1.03 per 100,000 women, respectively. of all carcinosarcomas, the incidence was highest in Blacks at 2.7 followed by 1.1 and 0.82 in Whites and Hispanics, respectively. Over the last 17 years, the annual incidence of carcinosarcoma has increased across all races, however for Black and Hispanic women that rate is increasing 2.5 times compared to Whites. More specifically, the percent increase was 3.7% per year for Blacks, 4% for Hispanics, and 1.5% for Whites. Black women in the 70–74 age group had the highest incidence of uterine carcinosarcoma at 21.6/100,000; while 60–64 year old Black women had the greatest percent increase of uterine carcinosarcoma at 3.3% per year.

Conclusions The incidence of ovarian and uterine carcinosarcoma is increasing across all races, but most notably for older Black women.

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