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EPV207/#484 Disparate trends in ovarian cancer in Asians living in Asia and the United States
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  1. C-I Liao1,
  2. E Thayer2,
  3. A Moon3,
  4. D Wong4,
  5. A Chan5,
  6. A Milki6,
  7. A Francoeur4 and
  8. J Chan7
  1. 1Kaohsiung Veterans General Hospital, Obstetrics and Gynecology, Kaohsiung City, Taiwan
  2. 2University of Massachusetts Medical School, Obstetrics and Gynecology, Worcester, USA
  3. 3Stanford University School of Medicine, Obstetrics and Gynecology, Division of Gynecologic Oncology, Stanford, USA
  4. 4University of California Los Angeles, Obstetrics and Gynecology, Los Angeles, USA
  5. 5Palo Alto Medical Foundation Research Intitute, Obstetrics and Gynecology, Palo Alto, USA
  6. 6George Washington University School of Medicine and Health Sciences, Obstetrics and Gynecology, Washington DC, USA
  7. 7California Pacific Medical Center, Obstetrics and Gynecology, San Francisco, USA

Abstract

Objectives To describe trends in ovarian cancer among native Asians and in the United States.

Methods Data were obtained from the United States Cancer Statistics (USCS) and Taiwan Cancer Registry of Taiwan Health and Welfare Data Center from 2001 to 2017. SEER*Stat 8.3.9, Joinpoint regression program 4.8.0.1, and Excel were used to calculate incidences and trends.

Results From 2001 to 2017, ovarian cancer incidence rose in native Asians (Taiwan) at a rate of 2.1% per year (p<0.001) while they fell in US Asians at 1.2% per year (p=0.026). Native Asians had increasing incidences of cancers of all cell types, with the fastest growth seen in rare ovarian tumors such as carcinosarcoma (6.4% per year, p=0.003), clear cell carcinoma (6.2% per year, p<0.001), and sex cord stromal (5.7% per year, p<0.001). Interestingly, although the overall incidence of ovarian cancer decreased in US Asians, the incidence of clear cell carcinoma rose 2.1% per year (p<0.001) in this group. In 2017, the peak age ovarian cancer in native Asians was 55–59 years old, younger than the peak in US Asians at 75–79 years old.

Conclusions From 2001 to 2017 the ovarian cancer incidence in native Asians rose, driven by increases in rare tumors, while the incidence in Asians living in the US declined, leading to 25% more cancers among native Asians than US Asians.

https://doi.org/10.1136/ijgc-2021-IGCS.278

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