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EPV206/#481 Preoperative evaluation of adnexal mass in breast cancer patients
  1. A Ennes1,
  2. M Wagner1,
  3. E Mayerhoff1,
  4. C Anton1,
  5. L Leite2,
  6. L Testa3 and
  7. J Carvalho1
  1. 1Instituto do Câncer do Estado de São Paulo, Ginecologia E Obstetrícia, Sao Paulo, Brazil
  2. 2AC Camargo Cancer Center, Oncologia, São Paulo, Brazil
  3. 3Instituto do Câncer do Estado de São Paulo, Oncologia Clínica, Sao Paulo, Brazil


Objectives Evaluation of ovarian cysts (OCy) are specially challenging in patients with a history of breast cancer (BC). We aimed to characterize a population of BC patients submitted to oophorectomy for OCy and establish risk factors for malignant findings on surgical specimen.

Methods All BC patients treated with oophorectomy for OCy between 2008–2021 at a tertiary hospital,were retrospectively reviewed.

Results 66 patients were eligible.Characteristics are described in table 1. Most (71.2%) had no cancer/benign lesions in the surgical specimens of the ovaries,10.6% had ovarian cancer,15.2% had BC metastasis and 3% had borderline lesions. Between the no cancer/benign/borderline the median IOTA-ADNEX/benign was 92.5%(IQR 62.6–96.6). Between the ovarian cancer the median IOTA-ADNEX/primary-malign was 83.7%(IQR 41–89.1). In the metastatic lesions the median IOTA-ADNEX/secondary-malign was 1.5%(IQR 0.3–12). The following variables were associated with a greater risk of malign ovarian histology: metastatic BC at diagnosis(p=0.01),ascites(p=0.004), elevated CA125(p=0.01), elevated CA15.3(p=0.002). Table 1.

Abstract EPV206/#481 Table 1

Conclusions CA125/CA15.3 are good pre-operative markers,IOTA-ADNEX is a good tool to distinguish bening cysts and OC.

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