Objectives Evaluation of ovarian cysts (OCy) are specially challenging in patients with a history of breast cancer (BC). We aimed to characterize a population of BC patients submitted to oophorectomy for OCy and establish risk factors for malignant findings on surgical specimen.
Methods All BC patients treated with oophorectomy for OCy between 2008–2021 at a tertiary hospital,were retrospectively reviewed.
Results 66 patients were eligible.Characteristics are described in table 1. Most (71.2%) had no cancer/benign lesions in the surgical specimens of the ovaries,10.6% had ovarian cancer,15.2% had BC metastasis and 3% had borderline lesions. Between the no cancer/benign/borderline the median IOTA-ADNEX/benign was 92.5%(IQR 62.6–96.6). Between the ovarian cancer the median IOTA-ADNEX/primary-malign was 83.7%(IQR 41–89.1). In the metastatic lesions the median IOTA-ADNEX/secondary-malign was 1.5%(IQR 0.3–12). The following variables were associated with a greater risk of malign ovarian histology: metastatic BC at diagnosis(p=0.01),ascites(p=0.004), elevated CA125(p=0.01), elevated CA15.3(p=0.002). Table 1.
Conclusions CA125/CA15.3 are good pre-operative markers,IOTA-ADNEX is a good tool to distinguish bening cysts and OC.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.