Objectives To evaluate clinicopathological features and survival outcomes of pure dysgerminoma of the ovary

Methods We retrospectively recorded clinicopathological and therapeutic data of 31 patients with pure dysgerminoma of ovary treated at the Salah Azaiez Institute of Tunisia between 1970 and 2012.

Results The median age was 22 years (12–60 years). The distribution of patients according FIGO stage was as follow:stage I:16 (51.6%),stage II:3 (9.7%),stage III: 11(35.5%) and stage IV:1 case.Radical surgery was performed in 11 patients and conservative surgery in 20 patients (64.5%) associated with node picking lymphadenectomy in 7 cases and complete lymphadenectomy in 7 cases. Complete macroscopic resection was obtained in 22 cases (70.96%) and lymph node metastasis was observed in 51.1% of cases. Adjuvant chemotherapy was indicated in 15 cases and adjuvant radiotherapy in 10 cases. After a mean time follow-up of 74 months (7–182 months), complete remission was observed in 26 patients. The 5-year progression-free survival (PFS) was 85.2%. The 5-year overall survival (OS) was 89.5% and was significantly decreased in the advanced stage (100% in stage I-II vs 75% in stage III-IV; p=0.02). There was a significant difference in OS and PFS between complete resection and residual disease groups (100% vs 67.5%;p=0.03 and 88.9 vs 75%;p=0.03, respectively).No difference in OS and PFS was noted following stratification by age ≤or>15 years (p=0.36 and p= 0.1), tumor size ≤or>20cm (p=0.27 and p=0.68) and conservative or radical surgery (p=0.87 and p=0.17).

Conclusions Macroscopic residual disease, as well as advanced FIGO stage, were the main prognostic factors in pure dysgerminoma of the ovary.