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466 Preoperative CA125 significantly improves risk stratification in high-grade endometrial cancer
  1. M Lombaers1,
  2. K Cornel1,
  3. N Visser2;3,
  4. F Amant4;5,
  5. P Bronsert6,
  6. P Geomini7,
  7. A Gil-Moreno8;9,
  8. D Van Hamont10,
  9. J Huvila11,
  10. C Krakstad12;13,
  11. M Koskas14,
  12. G Mancebo Moreno15,
  13. X Matias-Guiu16,
  14. B Pijlman17,
  15. C Vos18,
  16. V Weinberger19,
  17. M Snijders20,
  18. I Haldorsen12;21,
  19. C Reijnen22 and
  20. J Pijnenborg1;23
  1. 1Radboud University Medical Center, Dept. Obstetrics and Gynecology, Nijmegen, Netherlands
  2. 2Radboud University Medical Center, Dept. Pathology, Nijmegen, Netherlands
  3. 3Stichting PAMM , Dept. Pathology, Eindhoven, Netherlands
  4. 4KU Leuven , Dept. Oncology, Leuven, Belgium
  5. 5The Netherlands Cancer Institute (NKI), Center for Gynecologic Oncology , Amsterdam, Netherlands
  6. 6University Medical Center , Institute of Pathology, Freiburg , Germany
  7. 7Maxima Medical Center , Dept. Obstetrics and Gynecology, Veldhoven, Netherlands
  8. 8Vall d’Hebron Institut de Recerca, Biomedical Research Group in Gynecology, Barcelona, Spain
  9. 9Vall d’Hebron University Hospital, Dept. Gynecology, Barcelona, Spain
  10. 10Amphia Hospital, Dept. Obstetrics and Gynecology, Breda, Netherlands
  11. 11University of Turku, Dept. Pathology, Turku, Finland
  12. 12University of Bergen, Clinical Science, Bergen, Norway
  13. 13Haukeland University Hospital, Dept. Obstetrics and Gynecology, Norway
  14. 14Bichat-Claude Bernard Hospital, Dept. Obstetrics and Gynecology, Paris, France
  15. 15Hospital del Mar, Dept. Obstetrics and Gynecology, Barcelona, Spain
  16. 16Hospital Universitari Arnau de Vilanova, Pathology and Molecular Genetics and Research Laboratory, Lleida, Spain
  17. 17Jeroen Bosch Hospital, Dept. Obstetrics and Gynecology, ‘s-Hertogenbosch, Netherlands
  18. 18Elisabeth- TweeSteden Hospital, Dept. Obstetrics and Gynecology, Tilburg, Netherlands
  19. 19University Hospital Brno, Dept. Obstetrics and Gynecology, Brno-Bohunice, Czech Republic
  20. 20Canisius Wilhelmina Hospital , Dept. Obstetrics and Gynecology, Nijmegen, Netherlands
  21. 21Haukeland University Hospital , Mohn Medical Imaging and Visualization Centre, Department of Radiology, Norway
  22. 22Radboud University Medical Center, Dept. Radiation Oncology, Nijmegen, Netherlands
  23. 23Radboud Institute For Health Sciences, Nijmegen, Netherlands


Introduction/Background*Patients with high-grade endometrial carcinoma (EC) have an increased risk of lymph node metastasis (LNM). Preoperative serum CA125 and imaging findings have been incorporated in multiple risk stratification models to predict LNM and advanced disease in EC and are widely used in clinical practice. However, data on their predictive value in high-grade EC are limited. We therefore aim to determine the predictive value of CA125 combined with preoperative computed tomography (CT) imaging in high-grade EC for LNM.

Methodology Retrospective multicentre cohort study including patients (n=334) with preoperative high-grade EC and available CA125. Clinical data including imaging results, primary surgical treatment and final International Federation of Gynaecology and Obstetrics (FIGO) stage were recorded. CA125 was considered elevated at >35 IU/L.

Result(s)*Patients with high-grade EC (n=334) and elevated CA125 more often presented with advanced FIGO stage (III-IV), 64.2% (95/148) versus 18.8% (35/186) in patients with normal CA125 (p<0.05). For patients with elevated CA125 who underwent surgical staging (n=192), the prevalence of LNM was 56.5% (39/69), compared to 14.6% (18/123) in patients with normal CA125 (p<0.05). For patients with preoperative CT imaging (n=148), LNM were suspected in 18.9% (28/148), but histologically confirmed in 27.7% (41/148) of the patients. Preoperative CA125 and CT findings for LNM in relation to risk of LNM are shown in table 1.

Abstract 466 Table 1

CA125 and CT results in relation to lymph node metastasis (N1) in patients who underwent surgical staging

Abstract 466 Table 2

Logistic regression analysis of variables versus LNM

Multivariate analysis (table 2) showed that elevated CA125, histological deep (>50%) myometrial invasion, and cervical involvement independently predict histological LNM (p<0.05 for all) whereas positive CT findings for LNM did not.

Conclusion*This study demonstrates that elevated CA125 in patients with high-grade EC is an important prognostic marker for the predication of LNM and advanced stage disease. In patients with preoperative normal CA125, the additional value of CT imaging was limited with respect to the prediction of LNM. We therefore recommend to incorporate CA125 in routine preoperative work-up for risk stratification in high-grade EC.

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