Article Text

Download PDFPDF

387 Developing and validating ultrasound-based radiomics models for predicting high-risk endometrial cancer
  1. F Moro1,
  2. M Albanese1,
  3. L Boldrini2,
  4. V Chiappa3,
  5. J Lenkowicz2,
  6. F Bertolina3,
  7. F Mascilini1,
  8. R Moroni4,
  9. MA Gambacorta2;5,
  10. F Raspagliesi3,
  11. G Scambia1;6,
  12. AC Testa1;6 and
  13. F Fanfani1;6
  1. 1Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Rome, Italy
  2. 2Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC Radioterapia Oncologica, Rome, Italy
  3. 3IRCCS National Cancer Institute, Department of Gynecologic Oncology, Milan, Italy
  4. 4Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Direzione Scientifica, Rome, Italy
  5. 5Università Cattolica del Sacro Cuore, Istituto di Radiologia
  6. 6Università Cattolica del Sacro Cuore, Dipartimento Scienze della Vita e Sanità pubblica, Rome, Italy


Introduction/Background*Transvaginal ultrasound examination is the first imaging investigation for endometrial cancer. Ultrasound-based models for predicting high risk endometrial cancer have recently been published. However, none of these models includes radiomics features. Radiomics is an innovative high throughput technique extracting and translating high numbers of features from medical images into mineable data.

Aim of this study was to develop and validate ultrasound-based radiomics models, aiming to differentiating high risk category, as defined by ESMO-ESGO-ESTRO in 2016, versus the remaining categories of risk.

Methodology This is a multicenter retrospective observational study. Patients with histologically confirmed diagnosis of endometrial cancer who had undergone preoperative ultrasound examination between 2016 and 2019 were identified from two centers. Patients recruited in Center 1 (Rome) were included as ‘training set’ (n=396), while patients enrolled in Center 2 (Milan), as ‘external validation set’ (n=102). Radiomics analysis was applied to the ultrasound images. Clinical (including preoperative biopsy), ultrasound and radiomics features that proved to be different at the univariate analysis on the training set were considered for multivariate analysis and for developing ultrasound-based machine learning assessment models.

Result(s)*For discriminating high risk category versus the other categories one random forest model from the radiomics features (radiomics model), one binary logistic regression model from clinical and ultrasound features (clinical-ultrasound model), and another binary logistic regression model from clinical, ultrasound and previously selected radiomics features (mixed model) were created.

In the validation set, the radiomics model for predicting high risk showed AUC 0.80, sensitivity 58.7%, specificity 85.7%, positive likelihood ratio (LR+) 4.10 and negative likelihood ratio (LR-) 0.48; the clinical-ultrasound model showed AUC 0.87, sensitivity 67.3%, specificity 89.2%, LR+ 6.29 and LR- 0.37; and the mixed model showed AUC 0.88, sensitivity 67.3%, specificity 91.0%, LR+ 7.55 and LR- 0.36 (table 1).

Abstract 387 Table 1

Logistic regression models for discriminating high risk group versus other three groups, and low risk group versus the other risk groups for validation set

Conclusion*The mixed model including radiomics, clinical (including preoperative biopsy) and ultrasound features provided the best performance, even if the accuracy was slightly higher in comparison with the model based only on clinical and ultrasound variables. Interestingly, the model based only on radiomics features was able to provide good accuracy to discriminate high risk group versus the others.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.