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140 Characteristics and Patterns of Care of Endometrial Cancer before and during COVID-19 pandemic
  1. G Bogani1,
  2. G Scambia2,
  3. F Landoni3,
  4. V Zanagnolo4,
  5. E Sartori5,
  6. S Cianci6,
  7. A Ercoli6,
  8. F Fanfani2,
  9. R Angioli7,
  10. P De Iaco8,
  11. A Ciavattini9,
  12. L Aguzzoli10,
  13. V Remorgida11,
  14. P Benedetti Panici12,
  15. G Siesto13,
  16. V Chiantera14,
  17. E Zupi15,
  18. A Cianci16,
  19. T Simoncini17 and
  20. F Raspagliesi18
  1. 1Fondazione IRCCS Istituto Nazionale dei Tumori
  2. 2Policlinico Gemelli, IRCCS
  3. 3University of Milan Bicocca
  4. 4IEO
  5. 5University of Brescia
  6. 6University of Messina
  7. 7Campus Biomedico Roma
  8. 8University of Bologna
  9. 9Università Politecnica delle Marche, Ancona
  10. 10Azienda Unità Sanitaria Locale -IRCCS
  11. 11University of Eastern Piedmont, Novara, Italy
  12. 12La Sapienza di Roma
  13. 13Humanitas University
  14. 14University of Palermo
  15. 15University of Siena
  16. 16University of Catania
  17. 17University of Pisa
  18. 18Istituto Nazionale dei Tumori | Fondazione IRCCS


Introduction/Background*COVID-19 outbreak has correlated with the disruption of screening activities and diagnostic assessments. The risk of delayed diagnosis has consequently increased during the pandemic. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients.

Methodology This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: 03/01/2019 – 02/29/2020) and during (period 2: 01/04/2020 – 3/31/2021) the COVID-19 outbreak.

Result(s)*Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). The adoption of minimally invasive surgery was consistent in the two study periods (p=0.976). Before COVID-19 pandemic, 1,848 (72.8%), 666 (26.3%), and 25 (0.9%) patients had minimally invasive, open and vaginal surgery, respectively. During the COVID-19 pandemic, 1,663 (72.8%), 582 (25.5%), and 41 (1.7%) patients had minimally invasive, open, and vaginal surgery, respectively. Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2;p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had not adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy (in particular chemotherapy) use has increased during COVID-19 pandemic (p<0.001).

Conclusion*Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

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