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80 Concordance between preoperative ESMO-ESGO-ESTRO risk classification and final histology in early-stage endometrial cancer
  1. M Daix1;2;3,
  2. M Angeles1,
  3. F Migliorelli4,
  4. A Kakkos3,
  5. C Martinez Gomez1,
  6. K Delbecque5,
  7. E Mery6,
  8. S Tock7,
  9. E Gabiache6,
  10. M De Cuypere3,
  11. F Goffin3,
  12. A Martinez6,
  13. G Ferron6 and
  14. F Kridelka3
  1. 1IUCT Oncopole, Toulouse, France
  2. 2Clinical CHC Montlégia, Liège, Belgium
  3. 3Hospital Center Universitaire De Liege, Site N.-D. Des Bruyères, Liège, Belgium
  4. 4Hôpital Intercommunal Des Vallées De L’Ariège, Saint-Jean-de-Verges, France
  5. 5CHU De Liège, Liège, Belgium
  6. 6IUCT Oncopole, Toulouse, France
  7. 7Clinical CHC Montlégia, Luik, Belgium


Introduction/Background*The aim was to evaluate the concordance between preoperative ESMO-ESGO-ESTRO risk classification in early-stage endometrial cancer (EC) assessed by endometrial biopsy and magnetic resonance imaging (MRI) with this classification based on histology of surgical specimen.

Methodology This bicentric retrospective study included women diagnosed with early-stage EC (≤ stage II) who had a complete preoperative assessment and underwent a surgical management from January 2011 to December 2018. Patients were preoperatively classified into three degrees of risk of lymph node (LN) involvement based on endometrial biopsy and MRI. Based on final histological report, patients were re-classified using the preoperative classification. Concordance between the preoperative assessment and definitive histology was calculated with Cohen’s weighed kappa coefficient.

Result(s)*A total of 333 women were included and kappa coefficient of preoperative risk classification was 0.49. The risk was underestimated and overestimated in 37% and 10% of cases, respectively. Twenty-nine percent of patients had an incomplete LN staging according to the degree of risk of the re-classification. The observed discordance in the risk classification was attributed to MRI in 75% of cases, to the biopsy in 18% and in 7% to both (p <0.001). Kappa coefficient for concordance was 0.25 for MRI and 0.73 for endometrial biopsy.

Abstract 80 Table 1

Accuracy analyses of preoperative classification, endometrial biopsy and magnetic resonance imaging

Abstract 80 Figure 1

Concordance between preoperative risk classification assessed by endometrial biopsy and magnetic resonance imaging with the final histological analysis of the surgical specimen

Conclusion*Concordance between preoperative ESMO-ESGO-ESTRO risk classification and final histology is weak. Given that the risk was underestimated in the majority of patients wrongly classified, sentinel LN procedure instead of no LN dissection could be an option offered to preoperative low risk patients to decrease the indication of second surgery for re-staging and/or to avoid toxicity of adjuvant radiotherapy.

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